Ọ bụ ezie na ọnụ ọgụgụ buru ibu nke ụkwara ume ọkụ na-akpata nkwụsị nke eosinophilic, ndị ọrịa nwere mgbaàmà nke ụkwara ume ọkụ n'ihi ihe ndị ọzọ na-akpata mbufụt (eg basophil , lymphocytes , ma ọ bụ neutrophils ) agaghị enwe ike irite uru site na nlele anya FeNO. Dị ka akwụkwọ gbasara Clinical Practice Guideline sitere na American Thoracic Society, enwere ike iji MSN mee nchọpụta nke nchọnophilic mbufụ ma kwado nyocha nke ụkwara ume ọkụ ma ọ bụrụ na ọ dị mkpa ka e nwee ihe akaebe.
N'ikwu ya kpọmkwem, ọkwa dị elu nke FeNO na-egosi mmetụ na ngụgụ nakwa na onye ọrịa nwere ike ịzaghachi na ndị na- ekpuchi steroid dịka nchọpụta gara aga. N'ihi ya, ihe na-egosi IME na-eme ka a mata ihe nwere ike ịgwọ na ọgwụgwọ kama ịme nchọpụta kpọmkwem nke ụkwara ume ọkụ.
Nsogbu na nlekota omenala
Ihe kachasị atụmatụ atụmatụ ụkwara ume ọkụ na-agbazi ugbu a site na mgbaàmà ụkwara ume ọkụ ma ọ bụ na-eru oke. Ihe mgbaàmà ọdịnala dịka ịgba ume, ikpuchi obi , ụkwara , na mkpụmkpụ nke ume nwere ike ịbụ nke na-abụghị nke a kapịrị ọnụ, ọ dịghịkwa emetụta ụba nsị nke dị n'egwogị. E nwere ike iji nwayọọ nwayọọ jikọta ọnụ ọgụgụ kasị elu na ogo nke ikuku ikuku dị ka nchọpụta ụfọdụ si dị.
Uru nke FeNO For Monitoring Asthma
Ihe dị ka ọkara nke ọ bụla nke ụkwara ume ọkụ na-agụnye mmịnye ụgbọelu eosinophilic. Ụdị mmịnye a na-ebute site na regregulation nke mkpụrụ ndụ mast na mkpụrụ ndụ ndị ọzọ nke na-eme ka ọnụ ọgụgụ nitric oxide dịkwuo elu.
Dị ka e kwuru na mbụ, ndị nwere ọrịa eosinophilic emeela elu na ọkwa FeNO, ebe ndị ọrịa na-ekpo ọkụ site na ndị ọzọ na-akpata adịghị ebuli ọkwa FeNO. Tụkwasị na nke a, nchọpụta egosila na ọrịa biopsy gosipụtara na ndị ọrịa nwere ọkwa dị elu FeNO. N'ihi ya, a na-eche na ọkwa ndị dị elu FeNO na-achọpụta ndị ọrịa nwere ike ịzaghachi na ọgwụgwọ steroid na ọmụmụ egosiwo na ọkwa dị elu bụ ndị na-ekwu na ọ dị mma.
Nzọụkwụ na-adịghị mma
A na-atụle ọkwa na-adịghị na ya ugbu a na ụlọ ọrụ dibịa. Ndị ọrịa na-ekpochapụ kpamkpam wee were ume nkịtị site na nzacha nwere ike iwepụ. A na - enwezi ọkwa na-adịghị na ya na minit ole na ole maka nkọwa gị site na dọkịta gị.
A na-edekarị ọkwa, ọkwa, na elu dị na tebụl n'okpuru.
| Ndị okenye | Ụmụaka | |
|---|---|---|
| 12 na okenye | 4-12 | |
| Ala | <25 | <20 |
| Nkeji | ≥ 25- ≤ 50 | ≥ 20- ≤ 35 |
| Elu | > 50 | > 35 |
| ppb = akụkụ kwa ijeri | ||
Emeghi ihe eji eme ihe na Asthma Care
Nchọpụta Nchọpụta Nnyocha Na-enye Ọgwụgwọ kachasị mma bụ nchịkwa respiratory United Kingdom nke na-enweghị ihe ọmụma, data-esi nweta oge ndị na-arịa ọrịa ụkwara ume na UK. A na-enyocha nchekwa data ahụ iji chọpụta ndị ọrịa na-adịghị enweta ọgwụgwọ steroid na-ekesa kama ọ nwere ike irite uru na ndị ọrịa ndị a na-ejikwa ahụike na-eji MSN dịka akara.
Ndị nchọpụta chọpụtara na ọnụ ọgụgụ dị nta nke ndị dọkịta na-elekọta ndị na-agwọ ụkwara ume ọkụ na-eji FeNO. N'ụzọ na-adọrọ mmasị, a na-ejikọta nyocha nke FeNO na ntinye dịkwuo na usoro ọgwụgwọ na mgbakwunye na iji ya ibido ọgwụgwọ steroid ma ọ bụ ihe na-egosi maka ọgwụgwọ. Tụkwasị na nke a, nchọpụta ndị ọzọ egosila na ọnụ ọgụgụ nke ụkwara ume ọkụ na-adabere na ndị ọrịa na-eji MSN dịka akụkụ nke usoro nyocha ha.
Nnyocha e mere na United States na 10 oghere ụkwara ume ọkụ na-achọpụta na ọ bụrụ na e jiri ọgwụ na-eme ihe na-eduga na steroid ndị na-ekpo ọkụ ma ọ bụrụ na a tụnyere njikwa na-adabere na ntụziaka nke ụkwara ume ọkụ, ma nyere nnukwu mmụba nke mgbaàmà ụkwara ume ọkụ.
> Isi mmalite:
> Bateman ED, Boushey HA, Bousquet J. Nwere ike ịhazi njikarị ụkwara ume ọkụ? Ịchọta ezigbo ụkwara ume ọkụ > nchịkwa > ọmụmụ. Am I Res Resir Crit Crit Care Med 2004, 170: 36-844.
> Dwelk RA, Boggs PB, Erzurum SC et al. Otu Ntuziaka Na-ahụ Maka Ọgwụ Nlereanya nke ATS: Nkọwa nke Nitric Oxide Levels (FENO) maka Clinical Applications.
> Global Initiative for Asthma: Atụmatụ ụwa maka nchịkwa ụkwara ume ọkụ na mgbochi. 2012.
> Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, Brightling CE, Wardlaw AJ, Green RH. Nchịkọta ụyọkọ nyocha na ihe mgbaàmà nke ụkwara ume ọkụ. Am I Res Resir Crit Crit Care Med 2008, 178: 218-224.
> Langley SJ, Goldthorpe S, Custovic A, Woodcock A. Mmekọrịta n'etiti ọrụ mgbagwoju anya, reactivity bronchial, ma kpochapụ nitric oxide na nnukwu ìgwè nke ndị asthmatic.Ann Allergy Asthma Immunol2003, 91: 398-404.
> Mkpụrụ Obi, Ọkụ, na Ọbara. Nyocha Panel ọkachamara 3 (EPR3): Ntuziaka maka nyocha na Management nke Asthma.
> NHLBI / WHO Reporthop: Atụmatụ zuru ụwa ọnụ maka nchịkwa ụkwara ume ọkụ na mgbochi. Bethesda, MD. National Institutes of Health. Ulo Ochichi, Umu, na Obara; 1995. Ọhụụ nke 95-3659.