Methimazole, Carbimazole na Propylthiouracil / PTU
Mgbe ọkpụkpụ gịroid na-aghọ overactive - ọnọdụ a maara dị ka hyperthyroidism - gland na-emepụta ọtụtụ hormone thyroid. Nke a, n'aka nke ya, nwere ike ịme ọtụtụ mgbaàmà, gụnyere ngwa ngwa, ọbara mgbali elu, nchekasị, ehighi ura, tremor, ọnwụ, ọnwụ afọ, na ọtụtụ n'ime ihe ịrịba ama nke mgbochi ogwu, na ahịhịa na akụkụ.
Otu isi ọgwụgwọ maka hyperthyroidism bụ otu ụdị ọgwụ ọgwụ ndị a maara dịka ọgwụ antithyroid. A na-akpọkwa ọgwụ antithyroid dị ka thioamides. Ha bụ ọgwụ ọjọọ a na-eji agwọ ọrịa thyroid - hyperthyroidism - gụnyere mgbe thyroid bụ overactive n'ihi ọrịa Graves, ọnyá multinodular goiter, ma ọ bụ nodules ngbu.
Antithyroid ọgwụ ọjọọ na-arụ ọrụ site na igbochi thyroid gland ikike imepụta ihe abụọ igodo thyroid hormones thyroxine (T4) na triiodothyronine (T3).
Ndị isi ọgwụ antithyroid dị na United States dị methimazole na propylthiouracil (PTU). N'èzí United States, nhọrọ ndị a bụ methimazole, carbimazole, na PTU.
Methimazole
Na antithyroid ọgwụ methimazole inhibits thyroid si eji ayodiin - na-emekarị site na nri ma ọ bụ mgbakwunye - iji mepụta horroone thyroid. Ọ bụ ọgwụ a na-ewerekarị otu ụbọchị site n'aka ndị ọrịa.
Mgbe ụfọdụ, a na-akpọ Methimazole n'aha aha thiamazole.
A na-eji ọgwụ a gburugburu ụwa ma bụrụ isi ọgwụ antithyroid eji eme ihe na United States, ebe ọ dị n'okpuru aha aha Tapazole.
Ọtụtụ ndị na-ere ihe na-enyekwa ụdị methimazole.
Carbimazole
Carbimazole bụ ọgwụ na, mgbe a na-elekọta ya, a na-atụgharị ya n'ime ọgwụ methimazole na ahụ, ya mere, ọ bụ ya mere ya.
Ihe kacha mara amara nke carbimazole bụ Neomercazole.
Neomercazole bu aha ahia aha carbimazole ma Amdipharm International (UK) na-eme ya. E nyere ikike ọgwụ ahụ na 2004, ma na-ere ya na UK na Europe, ma ọ gaghị adị na ma ọ bụ edepụtara na United States. Ị nwere ike ịhụ datasheet na Neomercazole ebe a. Lee ọtụtụ ihe ndị ọzọ gbasara Neomercazole.
- Onye na-emepụta ọgwụ ọjọọ na-emepụta: Amdipharm
- Na-edepụta Ozi
Neomercazole Efrata : carbimazole Ph.Eur; lactose; ọka starch; sucrose; magnesium stearate; sucrose; talc; gum acacia; ferric oxide; propyl hydroxybenzoate; na gelatin.
E Nwere Ike : 5 mg
Ngwa / Aha ndị ọzọ: Carbimazole dị na mba Europe na Eshia n'okpuru aha ndị a: Atirozidina, Basolest, CG1, Carbimazole Spofa, Carbotiroid, Mertiran, Neo-Mercazole, Neo-Thyreostat, Neo-Tireol, na Tyrazol.
Propylthiouracil / PTU
Ụzọ PTU slows thyroid si overproduction nke thyroid hormone bụ na ọ inhibits thyroid gland iji iji iodine na-emepụta horroone thyroid. Ọ na-egbochi ntọghata nke thyroid hormone T4 n'ime T3. PTU nwere oge dị mkpirikpi, n'ihi ya, ndị na-aṅụ ọgwụ a na-emekarị ka a gwa ha ka ha were ọgwụ ahụ gaa okpukpu abụọ n'ụbọchị atọ iji mee ka mgbatị ọgwụ thyroid dị ala.
PTU nwere mmetụta ndị ọzọ karịa ọgwụ ndị ọzọ a tụlere n'ebe a, ọ bụkwa ọgwụ kachasị mma maka hyperthyroidism nanị n'ọnọdụ ole na ole (n'oge mmalite ime, oké mmiri ozuzo oyi na-egbu na mgbe onye ọrịa na-enwe mmetụta dị njọ site na methimazole).
Na United States, ọ bụ naanị PTU dị adị; ọ dịghị ụdị aha PTU na-ere ahịa na United States. Ọtụtụ ndị na-emepụta ihe na-emepụta PTU.
Ozi ndị ọzọ
Mụtakwuo banyere hyperthyroidism na ọgwụgwọ ya, gụnyere ọgwụ antithyroid, n'ime ihe ndị a:
- Mmetụta ọnyà nke Hyperthyroidism / Symptoms Listlist
- Mmetụta nke Ọrịa Siri Ike na Hyperthyroidism
- Ajụjụ Ndị A Na-ajụkarị Banyere Ọrịa Hyperthyroidism na Graves
- Ụzọ atọ a ga - esi na - emeso Hyperthyroidism
Isi mmalite:
Medieval Daily, Food Food na Drug Administration database, Online
Nkwurịta Okwu Nchedo FDA Drug: Ntị Ọhụụ Ọhụụ Ọhụụ Maka Ọrịa imeju na propylthiouracil, Eprel 21, 2010, Online
Ross, Douglas MD, "Ihe gbasara ọrịa: Antithyroid ọgwụ," UpToDate . Oge emelitere ikpeazụ: November 13, 2009