Ọrịa ogbu na nkwonkwo bụ ọrịa na-adịghị ala ala nke ọrịa ogbu na nkwonkwo . Ọ nwere ike ịga n'ihu na-eduga na nkwonkwo na nkwarụ na-adịgide adịgide. N'ozuzu, a na-ewere arthritis psoriatic dịka obere, mana ọ bụ ihe ndị ọzọ n'etiti ndị nwere psoriasis, na-emetụta n'etiti 6-10% nke ndị ọrịa psoriasis. Ọbụna nke ka ọtụtụ ndị nwere psoriasis dị njọ, na-emetụta 20-40% nke ìgwè ndị ọrịa ahụ.
Ọ dị mkpa ịmata ihe ize ndụ metụtara ọrịa arthritis psoria. Ihe kpatara ihe ize ndụ bụ njirimara ma ọ bụ ihe na-eme ka mmadụ nwee ike ịmepụta otu ọrịa ma ọ bụ ọnọdụ. Ihe ndi ozo di iche iche di iche iche ma obu ndi na-agbanweghi. Ihe nwere ike ime ka o nwee ohere iji gbochie oria ogbugba ogbugba ogwu ma obu ichikota mmebi nke o nwere ike ime.
Ihe njirimara nke ihe ojoo maka arthritis nke oma na-abia. Enwere ihe ọmụmụ ole na ole na-enyocha ihe ize ndụ maka ọrịa psoria ruo na afọ 2000. Enwebeghịkwa ọmụmụ ihe ole na ole nyochaworo ihe ize ndụ maka ịmepụta ọrịa arthritis n'etiti ndị nwere psoriasis. Ndị nchọpụta enwewo ike kwubie na ọrịa ogbu na nkwonkwo na-etolite site na mkpụrụ ndụ mkpụrụ ndụ, immunologic, na ihe ize ndụ gburugburu ebe obibi.
Mkpụrụ ndụ
Ihe dị ka pasent 40 nke ndị nwere psoriasis ma ọ bụ arthritis psoriatic nwere ndị ezinụlọ nwere psoriasis ma ọ bụ arthritis psoria. Nnyocha e mere egosiwo na ndị ọrịa nwere akụkọ ihe mere eme nke ezinụlọ nke ọrịa arthritis bụ ihe dị ka iri abụọ na isii na iri anọ na ise nwere ike ịmalite ọrịa ahụ karịa ndị na-enweghị akụkọ ntụrụndụ ezinụlọ.
A na-ewere ọrịa ogbu na nkwonkwo nke uche "dịka nke ọma" karịa ọrịa ndị ọzọ nke autoimmune .
Ụmụaka nne na nna nwere psoriasis nwere okpukpu atọ ka ha nwee ike ịmalite psoriasis ma nwee ohere dị ukwuu ịkwalite ọrịa arthritis psoriatic ma e jiri ya tụnyere ụmụ nke nne na nna na-enweghị psoriasis. Ọ bụrụ na ejima ejiri nwere eriri afọ psoria, otu ejima yiri nke ahụ nwere ike ịrịa ọrịa ahụ ma ọ bụ mee ya n'ikpeazụ. A na-ejikọta ọtụtụ mkpụrụ ndụ ihe nketa nke metụtara ọrịa na-arịa ọrịa ogbu na nkwonkwo na psoriasis. Ma, ọ bụghị mkpụrụ ndụ ihe nketa niile na-arịa ọrịa abụọ.
Immunologic
Ọdịdị dịgasị iche iche nke usoro ahụ ji alụso ọrịa ọgụ na-enye aka n'ịbawanye ohere nke ọrịa arthritis psoria. Mkpụrụ ndụ T na-arụ ọrụ dị n'ime anụ ahụ ma akpụkpọ ahụ na nkwonkwo. A na-echekwa na cytokines , dị ka TNF-alpha, na-ekere òkè n'ime usoro mkpali nke na-eduga ná mbibi cartilage na nsị anụ ahụ jikọtara ya na psthiotic ogbu na nkwonkwo.
Gburugburu ebe obibi
E nwere ihe gbasara gburugburu ebe obibi nke gosipụtara n'ihe ize ndụ nke ịmepụta ọrịa arthritis psoria. A na-elepụ anya na ọrịa ụfọdụ dịka ihe nwere ike ime, karịsịa ọrịa streptococcal. Enweghi ike gosipụta njikọ ma ọ bụ kwenye.
Ọrịa ogbu na nkwonkwo na-abakarịkarị na ndị mmadụ bu nje virus na-arịa ọrịa mmadụ (HIV) ma e jiri ya tụnyere ọha mmadụ.
Ihe a na-eme Koebner, nke na-eme na pasent 52 nke ndị psoriasis dịka Kelley's Textbook of Rheumatology si dị, a na-ewere ihe ọzọ gburugburu ebe obibi. Nke mbụ, Dr. Heinrich Koebner (onye na-ahụ maka mmuta nke dermatologist si na narị afọ nke 19) na 1876, ọnyá psoriatic na-etolite na akpụkpọ ụkwụ na-adịghị ahụkebe na-esote akpụkpọ anụ. Ihe na-akpata ihe ọ bụla Koebner ka na-edozi ma cytokines, protein ndị na-edozi ahụ, mkpụrụ ndụ adhesion, na autoantigens nwere ike itinye aka.
Isi mmalite:
Ịchọpụta Ihe Ndị Na-akpata Ọdachi Maka Ọrịa Ogbu na Nkwonkwo: Ọganihu Sayensị Na-ezute Mkpa Ọgwụ. Ogdie na Gelfand. JAMA Dermatology. July 2010.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917977/
Ozi onyonyo: Arthritis Psoriatic (E wezụga isi ihe) Gladman na Ritchlin. Kwalitere ruo ugbu a.
http://www.uptodate.com/contents/psoriatic-arthritis-beyond-the-basics
Arthritis Psoriatic. M. Elaine Husni. Cleveland Clinic. August 2010.
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/rheumatology/psoriatic-arthritis/
Onye na-eme Koebner. Clinics na Dermatology. Sagi L. na Trau H. March-April 2011.
http://www.ncbi.nlm.nih.gov/pubmed/21396563
Kelley's Textbook nke Rheumatology. Mbipụta nke itoolu. Elsevier. Isi nke 77. Arthritis Psoriatic. Oliver Fitzgerald.