Na ọrịa sickle cell , ugbu a ọgwụ kachasị mma anyị nwere iji gbochie nsogbu bụ a na-akpọ hydroxyurea, mgbe ụfọdụ a na-ebelata HU. A malitere imebi hydroxyurea dị ka ọgwụ na-agwọ ọrịa na afọ 1960. A na-eji ya maka ọnọdụ dịgasị iche iche dị njọ n'oge mbụ, mana e jiriwo ya na ọrịa sickle cell ugbu a ruo ihe karịrị afọ 25. Hydroxyurea bụ nanị FDA (Nri na Ọgwụ Nchịkwa) ọgwụ a kwadoro iji na-emeso ọrịa sickle cell anemia.
Kedu ka Hydroxyurea Si arụ ọrụ na Sickle Cell Anaemia?
Na ọrịa sickle cell, hydroxyurea na-enyere ahụ aka na-amịpụta hemoglobin nwa ebu n'afọ (Hb F). Nke a bụ hemoglobin dị na ụmụ ọhụrụ. Ụmụaka amụrụ ọhụrụ nwere ọrịa sickle cell enweghị nsogbu na ọnwa ole na ole mbụ nke ndụ n'ihi na hemoglobin nwa ebu n'afọ na-egbochi ọbara ọbara ọbara site na ọrịa sickling. Ọganihu a na-enwe na hemoglobin nwa ebu n'afọ na-enyere aka na-agbanye ọbara ọbara ọbara gị kama ịbụ ndị sickled. Mkpịsị ọbara ọbara uhie ndị a gburugburu nwere ike iji ọsọ na-asọba n'ime ọbara.
Kedu uru nke ọgwụgwọ Hydroxyurea?
N'ọmụmụ ihe dị iche iche ma ụmụaka ma ndị okenye nwere ọrịa hemel cell, ọgwụgwọ hydroxyurea ejikọtara ya na obere ọnyá na-egbu mgbu, obere ọrịa obi (mgbagwoju anya), imebi mkpa maka mmịnye ọbara, na belata mkpa maka ụlọ ọgwụ. Hydroxyurea na-emekwa ka hemoglobin gị dịkwuo ukwuu, na-eme ka ị ghara ibute ọrịa anumanu .
Ọzọkwa, a na-ejikọta ọgwụ hydroxyurea na ndụ ogologo ndụ n'ime ndị okenye nwere ọrịa aniare sickle cell.
Mmetụta dị n'akụkụ
Dabere na usoro a na-eji na sickle cell anaemia, mmetụta ndị dị na ya dịtụ nwayọọ. A naghị ahụkarị nhicha isi, ọnụ ọjọọ, na ọrịa ndị ọzọ metụtara ọrịa na-ejikarị chemotherapy.
Hydroxyurea nwere ike ibelata sel ọbara ọcha, hemoglobin, na platelets. N'ihi mmetụta a, onye dọkịta gị ga-eleba anya gị na ọnụ ọgụgụ ọbara zuru oke na ọnụ ahịa reticulocyte. Mgbe ụfọdụ, a na-ahụ ihe mgbu abdominal ma nke a na-adịkarị nwayọọ ma kpebie n'enweghị enyemaka. Mmetụta ọzọ dị na ya na-agba ọchịchịrị nke mbọ ndị a na-akpọ melanonichyia. N'ikpeazụ, ọtụtụ ndị ọrịa nwere ike ịchọta ọgwụ nke hydroxyurea ha nwere ike ịnagide obere mmetụta.
Olee Ndị Ọrịa Kwesịrị Ịtụle Ọgwụgwọ na Hydroxyurea?
Dika ntuziaka nduzi nke sickle cell kachasị na nso nso a sitere na National Heart, Lung, and Blood Institute (nke National Institute of Health) bipụtara n'afọ 2014, ụmụaka niile nwere hemoglobin SS na sickle beta zero thalassemia kwesịrị inye hydroxyurea ọgwụ iji gbochie nsogbu mgbe ọnwa 9 gasịrị. Na ndị okenye, a ghaghị ịtụle ọgwụgwọ hydroxyurea maka ndị ọrịa nwere nsogbu ọdụdọ atọ ma ọ bụ karịa kwa afọ, ihe mgbu nke na-emetụta ihe omume kwa ụbọchị, akụkọ ihe mere eme nke ọrịa ọrịa obi, ma ọ bụ ọrịa anaemia siri ike nke na-egbochi ihe omume kwa ụbọchị.
Hydroxyurea ọ na-akpata Ọrịa cancer?
Kemgbe ụwa, nke a bụ nnukwu nchegbu. Ndị ọrịa a na-emeso ya na hydroxyurea nwere ọnọdụ nke mere ka ha nwekwuo nsogbu nke ọrịa malignancy (cancer) ma n'ihi na ha malitere ịrịa kansa mgbe ha na-agwọ ọrịa hydroxurea ọ bụ ọgwụ ahụ.
N'ọrịa sickle cell, azịza ya abụghị. Dị ka otu nnyocha e bipụtara na 2014 na-achọ kpọmkwem ndị ọrịa nwere ọrịa sickle cell, ndị na-ewere hydroxyurea abụghị ọnyà dị ukwuu nke cancer ma e jiri ya tụnyere ndị na-adịghị ewere hydroxyurea.
Enwere m ike ijide mmiri ọgwụ mmiri mgbe ọ dị ime?
N'oge a a naghị atụ aro iji hydroxyurea n'oge ime. Hydroxyurea bụ ọgwụ D nke na-egosi na ọ nwere ihe ize ndụ nke ịzụlite nwa ebu n'afọ. E nwere ọnụ ọgụgụ dị nta nke na-akọ banyere ime ụmụ nwanyị na-arịa ọrịa sickle cell bụ ndị nọgidere na-enweta hydroxyurea ma a chọrọ ozi ndị ọzọ.
Enwere M Ike Kwụsị Iwere Hydroxyurea?
Ee e, hydroxyurea abụghị ọgwụgwọ. Ọ na-arụ ọrụ ma ọ bụrụ na ị na-ewere ya dị ka a gwara. Hydroxyurea bụ ọgwụ na-adịghị ala ala maka ọrịa na-adịghị ala ala yiri ọgwụ ndị nwere ọbara mgbali elu kwa ụbọchị.
> Isi mmalite:
> Castro O, Nouraie M, Oneal P. Hydroxycarbamide Ọgwụgwọ na Ọrịa Sickle Cell: Atụmatụ nke Ọ Ga-ekwe Omume Egwu Egwu na nke Ụlọ Ọrụ Ịgba Ọgwụ. British Journal of Hematology . 2014; 167: 687-691.
> Ware RE. Otú m si eji Hydroxyurea na-emeso ndị ọrịa na-eto eto. Ọbara . 2010; 115 (26): 5300-5311.