Nicotine ọ na-akpata ọrịa cancer ma ọ bụ mee ka ọrịa cancer gbasaa? Mmetụta dị aṅaa ka nicotine nwere n'ahụ ọrịa cancer? Dika otutu ihe ndi na-ese anwuru nwere nicotine ga-abia, ihe ndi a di mkpa. Na njedebe dị oke uru uru ọgwụgwọ nicotine-ọ nwere ike inyere ndị mmadụ aka ịmara àgwà a na-akpata ọrịa kansa (na ọtụtụ ọrịa ndị ọzọ). N'aka nke ọzọ, ndị mmadụ na-ekwu na nicotine nwere ike ịnwụ nakwa na e ji ya mee ihe mbụ. dị ka ụmụ ahụhụ.
Mmetụta nke Nicotine na Ọrịa
Iji zaa ajụjụ a-ọrụ nke nicotine banyere cancer-a ga-agbagharị ajụjụ a n'ọtụtụ isiokwu. Dị ka nke a, anyị kwesịrị inyocha ọrụ nicotine na-esonụ:
- Mmalite Tumor ma ọ bụ Mutagenicity - Nke a na-ezo aka n'ikike nke ihe na-akpata mmebi (ngbanwe na DNA) dị mkpa iji tọghata sel nkịtị n'ime cell cancer .
- Nkwalite Tumor / Tumor Ọganihu - Nke a na-ezo aka n'ikike nke ihe na-eme ka ụbụrụ dị ugbu a na-etowanye ngwa ngwa na / ma ọ bụ na-agbasa (metastasize) na mpaghara ndị ọzọ nke ahụ ngwa ngwa.
- Mmetụta na Ọgwụ Ọrịa Cancer - Nke a na-ezo aka na mmetụta nke ahụ nwere ike ịnweta ọgwụgwọ ọrịa kansa, dịka ọmụmaatụ, ma ọ bụrụ na ihe ejide ma ọ bụ gbochie ihe nke ọgwụ ọgwụ.
Ọrụ Ngwakọta Nicotine na Ọrịa Cancer
Ọ bụ ezie na a dịghị eduzi ọmụmụ ihe na ncotine niile nwere ike ịgwọ ọrịa niile. Na, ọtụtụ n'ime ọmụmụ ihe na-eme ugbu a na ụmụ oke, oke, ma ọ bụ na mkpụrụ ndụ cancer na-eto na ụlọ nyocha, anyị maara ihe ndị a:
- Mmetụta nke Nicotine na Mmalite Tumor ma ọ bụ Mutagenicity - Nnyocha e mere n'oge na-adịbeghị anya egosiwo na nicotine nwere mmemme mutagenic na nke na-eme tumor. Enwerekwa ihe akaebe na nicotine nwere ike imebi DNA-ụdị mmebi nke nwere ike ibute ọrịa kansa. E nwekwara ihe àmà na-egosi na nicotine na-eme ka usoro carcinogenesis pụta ìhè-nke pụtara na usoro nke cell na-aghọ nkwonkwo na nzaghachi nye ihe ọzọ dị na ya. Nke a apụtaghị na ọ dị ize ndụ nye ndị na-enweghị kansa. Ihe ndị dị n'okpuru ebe a nwere ike ime mgbe ọnyá dị ugbu a ma a chọpụtabeghị.
- Mmetụta na Nkwalite Tumor na Ọganihu - Ọ bụ ezie na nicotine nwere ike ọ gaghị abụ ihe kpatara mkpụrụ ndụ mbụ n'ime ụbụrụ na-aghọ nkwonkwo, ọtụtụ nnyocha ndị ọzọ egosiwo na ozugbo ọrịa kansa malitere, nicotine nwere ike ịkwalite uto nke ụbụrụ ahụ. Dịka ọmụmaatụ, achọtala nicotine iji kwalite ọrịa nke pancreatic cancer na ụmụ oke. A chọpụtakwara na ọ na-akwalite mmụba, mbuso agha, na mpụga nke mkpụrụ ndụ tumo na ọrịa cancer akwara obere obere.
- Mmetụta dị na Nzaghachi na Ọrịa Cancer - A chọpụtala Nicotine iji gbochie ụfọdụ n'ime ọgwụgwọ maka ọrịa kansa, nke nwere ike ịpụta na nicotine nwere ike belata ọnụego ndụ na ọrịa cancer. Dịka ọmụmaatụ, nicotine nwere ike ịkwalite ịdọrọ ọgwụ ọgwụ chemotherapy Platinol (cisplatin) n'ime mkpụrụ ndụ kansa cancer.
Ọ dị mkpa iburu n'obi na, n'ọtụtụ n'ime nchọpụta ndị a, a na-enyocha nicotine dị iche na ụtaba siga na iji hụ na mmetụta dị na nicotine nanị karịa ihe ndị ọzọ dị na ụtaba.
Olee otú Nicotine si arụ ọrụ iji kwalite Ọrịa Cancer ma gbasapụ ma belata nhazi ọgwụgwọ
E nwere ụzọ dịgasị iche iche e si chọta nicotine iji metụta uto na mgbasa nke cancer.
Ndị a gụnyere:
- Ịmalite ịmalite ịrịa kansa (dịka e kwuru n'elu).
- Na-eme ka ụbụrụ na-eto eto (site na ndị na-edozi ahụ na-edozi ahụ bụ ndị na-arụ ọrụ nke nhazi na mkpụrụ ndụ).
- Ime ka cancer gbasaa (dịka ọmụmaatụ, site na ime ka mkpirisi nke mkpụrụ ndụ cancer (dịka e kwuru n'okpuru ebe a).
- Enhancing angiogenesis - Nicotine nwere ike ime ka ikike nke ọrịa cancer nwee ike ịmepụta arịa ọbara ndị dị mkpa maka ibu na igbochi ọnwụ nke mkpụrụ ndụ ndị agadi ma ọ bụ ndị na-adịghị ahụkebe (apoptosis.)
- Na - eme ka a na - enye aka - site na - akpali ụzọ dịgasị iche iche, nicotine nwere ike ime ka ụbụrụ bụrụ nke na - adịchaghị mfe nye ndị ọrụ chemotherapy.
Ọ bụ ezie na ịkọwapụta usoro ndị ahụ dị oke aka na-arụ ọrụ nke ọma na ihe karịrị akarị nke isiokwu a, ihe atụ ole na ole nke ụzọ nicotine si chọpụta ọganihu na mgbasa nke ọrịa cancer gụnyere:
- Nicotine nwere ike ịrụ ọrụ site na ya na ndị nabatara ndị ncotinic acetylcholine receptors (nAChRs). N'ezie, nke a bụ ụzọ nicotine si eri ahụ. Site n'ịkwalite nicotine ndị a na-anabata ya nwere ike ime ka ụbụrụ na-eto eto, kwalite ọkpụkpụ ọbara ndị dị mkpa maka ọrịa cancer iji na-eto ( angiogenesis ) ma gbochie ọnwụ (apoptosis) nke mkpụrụ ndụ cancer. Ebe ọ bụ na ọdịiche dị n'etiti ndị ncotinic acetylcholine receptors n'etiti ndị dị iche iche, mmetụta ndị a pụkwara ịdịgasị iche n'etiti ndị dị iche iche. (N'ụzọ na-akpali mmasị, ịṅụ ọgwụ ike na nicotine siri ike na-ejikọta ya na nnukwu nsogbu nke cancer cancer.)
- Nicotine na-akpali protein nke a maara dị ka beta-arrestin-1. Mkpụrụ a, n'aka nke ya, na-eme ka mkpịsị ọbara cancer na-eme ka ha gbasaa ma wakpo ngwa ngwa.
Ọrịa Na - ejikọta na Nicotine na Ụfọdụ Ụzọ
Enweghi ike imuta ihe gbasara nicotine na nchoputa, oganihu, na nzaghachi nye oria ogwu, ma enwere ihe akaebe na nicotine nwere ike ime ihe ojoo ma obu otu uzo maka oria ogwu ndia:
- Ọrịa cancer ara ntakịrị
- Ọrịa cancer na-adịghị obere obere
- Ọrịa isi na olu
- Ọrịa gastric (cancer cancer)
- Ọrịa Pancreatic
- Ọrịa Gallbladder
- Ọrịa cancer
- Ọrịa Colon
- Ọrịa ara
- Ọrịa cancer
- Ọrịa na-egbu egbu
- Ọrịa akụrụ (cancer akwara)
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