NSAIDS so n'òtù Akwụsị Ọrịa Ogbu na nkwonkwo
NSAIDs (ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ) na-alụso ọrịa ogbu na nkwonkwo site na itinye aka na usoro mkpesa. NSAIDs bụ nnukwu ìgwè ọgwụ ndị a na-ejikarị agwọ ọrịa ogbu na nkwonkwo n'ihi na ha:
- analgesic (ihe mgbu-egbu)
- ihe mgbochi mkpali
- antipyretic (ihe ọkụ)
NSAID Categories
E nwere ụdị NSAI atọ:
- salicylates (ma ọ bụ acetylated, dị ka aspirin , na nke na-enweghị afọ)
- NSAID omenala
- COX-2 nhọrọ nchịkwa
NSAID ndị a na-ejikarị arthritis gụnyere:
- Ansaid (aha njirimara flurbiprofen)
- Arthrotec (aha njirimara diclofenac na misoprostol)
- Aspirin (acetylsalicylic acid)
- Cataflam (Grik aha diclofenac potassium)
- Celebrex (aha njirimara celecoxib)
- Nyocha (generic name sulindac)
- Daypro (ọnụọgụ aha oxaprozin)
- Disalcid (aha salsalate aha)
- Dolobid (aha njirimara aha)
- Feldene (aha njirimara piroxicam)
- Ibuprofen (aha ndị ọzọ gụnyere Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (aha njirimara aha njirimara)
- Ketoprofen (aha aha gụnyere Orudis, Ọrụ, Actron, Orudis KT)
- Lodine (aha njirimara etodolac)
- Meclomen (aha igwe meclofenamate sodium)
- Mobic (aha njirimara aha)
- Nalfon (generic aha fenoprofen)
- Naproxen (aha aha gụnyere Naprosyn, Aleve, Naprelan, Anaprox)
- Ponstel (gọọmentị aha mefenamic acid)
- Relafen (generic name nabumetone)
- Tolectin (generic name tolmetin sodium)
- Mee ka amara (aha ọnụọgụ aha choline magnesium trisalicylate)
- Voltaren (aha njirimara diclofenac sodium)
Olee otú NSAIDs na-arụ ọrụ
N'okwu dị mfe, NSAID na-arụ ọrụ site n'ịbelata mbufụt. Ha na-eme nke a site na igbochi enzyme isi nke mbufuru nke a na-akpọ cyclooxygenase, nke na-eme ka arachidonic acid ghọọ prostaglandins na leukotrienes.
Ihe ndị na-eme ka ndị na-eme ihe ọjọọ na-eme ka ahụ nwee ahụ. Ya mere, site na igbochi cyclooxygenase, NSAID belata mmetụ .
Otu NSAID nwere ike ịrụ ọrụ maka gị karịa otu ị nwara tupu - ma ọ bụ na ọ gaghị arụ ọrụ ma ọlị. Nke a bụ n'ihi ihe a na-akpọ dịka iche iche ọgwụcokinetic - usoro nke eji etinye ọgwụ, kesaa, metabolized, na kpochapụ.
More na Enzyme Cyclooxygenase
E nwere ụdị abụọ nke cyclooxygenase, nke a maara dịka COX-1 na COX-2. COX-1 na-etinye aka na ịnọgide na-enwe ahụ ike na akụrụ. COX-2 bụ enzyme nke kpatara mbufụt. N'ihi na ndị NSAID omenala na-egbochi ma ọ bụ COX-1 na COX-2, ha nwere ike ịnweta mmetụta ndị na-achọghị, dị ka iwe iwe ma ọ bụ ịrụ ọrụ akụrụ. Ọ bụ ya mere ndị nchọpụta ji mepụta NSAIDS nke na-egbochi COX-2. Ndị a na-etinye aka na COX-2 bụ ndị ọhụrụ NSAID.
Ọrụ FDA maka NSAID niile
N'afọ 2004, onye na-emepụta ihe na-eme ihe na-ewepu Vioxx na-emepụta ya site n'ahịa mgbe ọ gụsịrị akwụkwọ gosiri ogologo oge o nwere ike ime ka ọnyá obi na ọrịa strok mụbaa. Nyocha nyochaa site na Nchịkwa nri na ọgwụgwọ US na-eduga na 2005 chọrọ ka ndị na-abụghị aspirin NSAID buru ịdọ aka ná ntị yiri ya.
Ọ dị mkpa ka gị na dọkịta gị kwurịta nsogbu ndị a. (Ọ bụ naanị otu onye na-eme ihe na COX-2 na - ere ahịa - Celebrex.)
Ịdị mma nke NSAID
- Mgbu na mbufụt na -eme mgbe ụfọdụ n'ime oge a na-agbapụta ụda (nkedo rhythmic kwa ụbọchị dabere na oge awa 24). Ya mere, NSAID nwere ike ịdị irè karị n'oge ụfọdụ.
- Ihe dị ka pasent 60 nke ndị ọrịa ga-azaghachi NSAID ọ bụla. Oge ikpe nke izu atọ ga-enye gị ohere zuru ezu ịmara ma ọ bụrụ na ọgwụ ahụ na-arụ ọrụ maka gị. N'ụzọ dị mwute, ihe dịka pasent 10 nke ndị ọrịa ọrịa ogbu na nkwonkwo ga-ahụ NSAID anaghị arụ ọrụ maka ha.
- NSAIDs nwere ike ichebe ihe ịrịba ama na mgbaàmà nke ọrịa.
- Mmetụta ọjọọ nke NSAID nwere ike ime mgbe ọ bụla gụnyere akụrụ akụrụ, imeju umeji, ọbara ọgbụgba, na ụdọ (afo) ọnyá.
- NSAIDs (karịsịa indomethacin) nwere ike igbochi ọgwụ ndị eji ejide ọbara mgbali elu na ọdịda obi mgbaka (dịka ndị na-emegide beta-adrenergic, angiotensin-na-emegharị ndị na-emechi enzyme, ma ọ bụ diuretics).
- Ụfọdụ nnyocha ọmụmụ na-atụ aro iji NSAID mee ogologo oge nwere ike mee ngwa ngwa na-agbagha nkwonkwo cartilage, ma a chọkwuru nnyocha.
Ndabere ala
Enweghị ike ịkọ amụma nke NSAID ga-enyere gị aka. Enweghị otu NSAID dịka aka karịa ndị ọzọ maka enyemaka mgbu. Ozugbo a choro NSAID, a ghaghị ịgbatị usoro ahụ ruo mgbe a kwụsịrị ihe mgbu ma ọ bụ ruo mgbe o ruru ogo kachasị. Mmeghachi omume nke onye ọrịa kwesịrị ịbụ ihe nduzi maka ịhọrọ ọgwụ kwesịrị ekwesị, jiri ọgwụ kachasị dị ala nweta iji nweta ahụ efe. Na-atụle uru na izere ihe ize ndụ nke NSAID na dọkịta gị.
> Isi mmalite:
> Ụlọ akwụkwọ Medical Center nke Center nke Arthritis, David S. Pisetsky, MD, Ph.D. 1995.
> New England Journal of Medicine, 324 (24): 1716-1725, 1991