Technivie (ombitasvir + paritaprevir + ritonavir) bụ ọgwụ na-ejikọta ọnụ na ọgwụ ọjọọ ejiri mee ihe maka ịgwọ ọrịa ịba ọcha n'anya nke C (HCV) . Ndị ọrụ atọ ahụ nke gụnyere Technivie na-ejikọta na ọgwụ abụọ HCV, Viekira Pak .
A kwadoro Technivie na July 24, 2015 site na US Food and Drug Administration (FDA) maka ndị okenye 18 afọ ma ọ bụ karịa na ọrịa HCV genotype 4 (GT4) na-enweghị cirrhosis .
Technivie bụ nke mbụ, ọgwụ niile, na-enweghị ọgwụgwọ HCV maka ọrịa maka ndị ọrịa GT4 ọrịa HCV na-adịghị ala ala, a na-ele ndị mmadụ anya n'ụzọ siri ike ịgwọ.
E kwuru na Technivie ga - enweta ọgwụgwọ 100% nke ndị na - arịa ọrịa n'oge gara aga ("naïve ọgwụgwọ") bụ ndị na - arịa ọrịa n'oge a na - ekpe IIb ikpe e mere site n'August 12, 2012 ruo November 19, 2013.
Ọgwụgwọ
Mbadamba nkume abua (12.5mg ombitasvir, 75mg paritaprevir, 50mg ritonavir) were kwa ụbọchị na-eri nri n'enweghị mkpa maka nnukwu abụba ma ọ bụ ihe oriri caloric. Mbadamba technivie bụ pink, oblong na-ekpuchi film, na "AV1" jupụtara n'otu akụkụ.
Na-akọwa ndụmọdụ
A na-eji usoro Technivie mee ihe na izu iri na abụọ n'iji ribavirin (ọgwụ a na-eme iji gbochie RNA synthesis). Ụdị na-atụ aro nke ribavirin dabeere na arọ, dị ka ndị a:
- Ihe na-erughị 165 lbs (75kg): 1000mg kwa ụbọchị, ekewa ma na-enye ya nri ugboro abụọ kwa ụbọchị
- 165 lbs (75kg) na n'elu: 1250mg kwa ụbọchị, kewara ma na-enye ya nri ugboro abụọ kwa ụbọchị
A na-atụle usoro izu iri abụọ na abụọ nke Technivie maka ọgwụgwọ ọrịa na-adịghị mma nke na-enweghị ike ịnagide ribavirin.
Mmetụta Na-agakarị
Ihe ndị ọzọ kachasị emetụta metụtara Technivie (na-eme na ọ dịkarịa ala pasent 7 nke ndị ọrịa) bụ:
- Ọdịdị anụ ahụ
- Ike ọgwụgwụ
- Nausea
- Mkpụrụ obi
- Rash
Ngwunye ọgwụ
E kwesịghị ịṅụ ọgwụ ndị na-esonụ mgbe ị na-eji Technivie:
- Anticonvulsants: Tegretol, Dilantin, Trileptal, phenobarbital
- Antipsychotics: Orap
- Ọgwụ Antiretroviral: Sustiva
- Cholesterol-lowering statin drugs: Altoprev, Mevacor, Zocor
- Ihe na-emepụta ọgwụ na-adịghị ọcha Erectile: Revatio
- Ihe mgbapụta nke ergot (eji agwọ ọrịa isi): 45, Ergomar, Ergotrate, Hydergine, Migranal
- Mmebi ọgwụ Estinyl estradiol: Estinyl, Apri, Reclipsen, Azurette, Kariva, Yaz, Yasmin, Ocella, Vestura, Beyaz, Safyral, Zovia, Demulen, Demulen 1/35, Kelnor 1/35, Nuva Ring, FaLessa, Lutera, Alesse , Seasonique, Aviane, Ortho Evra, Xulane, Lo Loestrin Fe, Necon 1/35, Fee 24 Fe, Loestrin 24 Fe, Ortho Tri-Cyclen, Sprintec, Ortho Tri-Cyclen Jiri, Tri-Sprintec, Cryselle, Lo / Ovral, Ovral, Elinest
- Mcobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin na Rifampin ọgwụ.
- Ebum n'uche: Amaokwu, Halcion
- John Wort
Nkwekọrịta na Ntụle
A naghị atụ aro Technivie maka ndị nwere ọrịa na-adịghị mma na-arịwanye elu (Child-Pugh score B) ma na-emegide ya na ndị ọrịa na-arịa ọrịa hepatic siri ike (nwa-Pugh score C).
A na-egbochi technivie iji mee ihe na ndị ọrịa nwere hypersensitivity amara na ritonavir (ya bụ, ndị nwere ahụmahụ Stevens-Johnson ma ọ bụ ọnya epidermal necrolysis).
Ọ bụ ezie na Technivie n'onwe ya adịghị emegide ya maka iji ya eme ihe, Nchikota Technivie na ribavirin bụ ma kwesịghị iji ya ma ọ bụ ndị inyom dị ime ma ọ bụ ndị nwoke na nwanyị dị ime. N'ihe banyere inye nwa ara, ọ dịghị enwe mmetụta nke ụbụrụ nwa ebu n'afọ na-amụba n'ọmụmụ anụmanụ; a na-atụ aro ka ọkachamara ọkachamara tụlee uru ndị nwere ike ịba na mmetụta ọjọọ nke ị na-aṅụ ara mgbe ị na Technivie.
Isi:
Nchịkwa nri na ọgwụgwọ US (FDA). "FDA kwadoro Technivie maka ọgwụgwọ ọrịa ịba ọcha n'anya nke C 4." Silver Spring, Maryland; nkwupụta mgbasa ozi nyere July 24, 2015.
Hézode, C .; Asselah, T .; Reddy, R .; et al. "Ombitasvir tinyere paritaprevir tinyere ritonavir na ma ọ bụ na-enweghị ribavirin na ndị na-agwọ ọrịa na ndị na-agwọ ọrịa nwere ọrịa genotype 4 ọrịa na-arịa ọrịa ịba ọcha n'anya C (PEARL-I). Lancet. June 20, 2015; 384 (9986): 2502-2509.