Enweela mmasị na iji ntinote na ihe omimi na nkà mmụta ọgwụ. Mmetụta ndị na-anaghị emebi emebi nke na-achọpụta ihe ịrịba ama dị mkpa, yana ngwaọrụ ndị na-eme ihe na-eme ka usoro dịkwuo mfe, na-aga n'ihu ugbu a. Akụkụ ọzọ dị mkpa nke ọganihu na nanotechnology bụ mmepe nke nanoparticles nwere ike ibu ọgwụ ma lelee sel ma ọ bụ anụ ahụ kpọmkwem.
Ndị a nano "drones" nwere ike inwe nnukwu ikike na usoro ọgwụgwọ dịgasị iche iche. Ha abanyelarị na oncology ma mee ka ha ghara iji ọgwụ ndị na- agwọ ọrịa na-eme ka ha ghara ịkwa mma . N'afọ 2015, ndị ọkachamara na ọrịa obi na-ejikwa ọgwụ na-agwọ ọrịa na-emepụta ọgwụ na ịrụzi akwara , na-edozi ụzọ maka ịgwọ atherosclerosis n'ụzọ dịgasị iche, ikekwe igbochi mmetụ obi na strok.
N'iji Nanotechnology iji dozie mbufụt
Nyocha nke ụdị anụmanụ, nke e bipụtara na Science Translational Medicine , kọrọ na drones nano-sized nwere ike ịdị irè n'ime nhazigharị ihe oyiyi atherosclerotic, na-eme ka ihe ncheta ahụ kwụsie ike ma na-adịkarị ka ọ ga-agbaji ma ghọọ nnukwu ọnya ọbara. Ndị na-eme nchọpụta na Harvard Medical School, Brigham na Ụlọ Ọgwụ Ndị Na-ahụ Maka Ụmụaka na Columbia na-emepụta nanomedicines nke a na-arụ ọrụ iji buru ihe ndị na-egbochi ihe ọkụkụ na-aga n'ihu na saịtị ahụ.
Ọ bụghị ikpebi mbufụt bụ ihe bụ isi kpatara ọganihu nke ọnya atherosclerotic.
Mgbe eji nano drones nke nwere ihe ngwọta nke sitere na mgbochi inflammatory protein annexin A1, enwere ọganihu dị mma na ụmụ oke nwere oke atherosclerosis. Ọ bụghị nanị na mbufụt ahụ belata, akwara nke ụmụ oke ahụ mekwara ka ọ dịzie, otu akụkụ nke ọgwụgwọ nke pụrụ iche na ụdị ọgwụgwọ ọhụrụ a.
Ighaghachi ihe akwara akwara nke nwere ike ime ka ọ dị ezigbo mkpa maka igbochi mkpata obi mgbu, ọ pụkwara igbochi ọnụ ọgụgụ ọnwụ nke atherosclerosis, bụ nke bụ isi ihe kpatara ọrịa na ọnwụ na United States. Ekwuola na usoro mmeghari ohuru ga-abụ nke ọma ma nyochaa ụmụ mmadụ, na-enye ụzọ na-akpali akpali isi na-emeso nsị na-echebara echiche, nke a na-ahụ maka peptides.
Ndị nchọpụta si Weldon School of Biomedical Engineering, Mahadum Purdue, kọwara ụzọ ọzọ a ga-esi nwee ike ịgwọ nsị na-eji nanotechnology. Ha mepụtara usoro ntanopicicle na-ejikọta ọnụ na-ejikọta ọnụ nke nwere ike iji mee ihe maka ịgwọ ọrịa akwara afọ. Usoro ohuru a na - eji nanoparticles na - agbanye aka na collagen ma wepu peptides mgbochi mkpali. Ihe ndị a nwere ike ibelata mbufụt, yana ịkwalite nchịkwa nke anụ ahụ merụrụ ahụ.
Ntughari nke Epithelial na Nanoparticles
Mgbochi mgbochi bụ mpaghara ọgwụgwọ ọzọ ebe a pụrụ iji ngwa ngwa mee ihe iji kwado usoro ọgwụgwọ siri ike. Giovanna Leoni na ndị ọrụ ibe na Mahadum Emory na-eji usoro ntinye nke nanoparticles nwere protein sitere na ya na annexin A1 na eriri afọ mgbu ahụ.
Ọrịa na-adịghị ala ala nke na-adịghị ala ala bụ akụkụ nke ọtụtụ ọnọdụ mkpali nke obi, gụnyere ulcerative colitis na ọrịa Crohn-ọnọdụ nke na-emetụta ihe ruru nde mmadụ nde America. Nnyocha e mere n'oge na-adịbeghị anya na ụmụ oke gosipụtara na ịkwado maka nnyefe nke mgbochi ndị na-egbu egbu na-eme ka usoro ọgwụgwọ nke anụ ahụ merụrụ ahụ dịkwuo elu ma na-akwalite mmebi mmebi ahụ. N'akwụkwọ ha, nke e bipụtara na Journal of Clinical Investigation , ndị na-ede akwụkwọ na-ekwu na ndị na-ahụ maka peptides na-ekpuchi n'ime nanoparticles nwere ike ịbụ usoro ọgwụgwọ ọhụrụ maka ndị mmadụ na-arịa ọrịa stroel ọrịa (IBD).
Enwekwara mmasị na mmepe nke ihe ndị dị ndụ na-enyere aka na-emeso ọnọdụ dị ka IBD. A na-eji ihe omimi nke a na-enweta site na ginger oriri na-eme nke ọma na ọmụmụ nke MingZheng Zhang nke Georgia State University, Atlanta. Ihe ndị na-emepụta ihe ndị dị na mbara igwe nwere ike ibelata ihe isi ike ndị metụtara na mmepụta kemịkị sịntetik.
Ngwongwo Nanomesh maka Ọrịa Na-adịghị Ala
Martina Abrigo na ndị otu ndị na-eme nchọpụta na Ahịa Australia nke Swinburne University nke Technology gosipụtara ikike ọzọ maka nanotechnology. Abrigo na-achọgharị ihe mpempe akwụkwọ nke obere obere ahụ iji mesoo ọnyá ndị na-egbu oge. O mepụtara ntupu site na electrospun polystyrene na-emepụta iji dọpụta nje bacteria na ọnya ahụ. Nanomesh na-enye ezigbo ọnọdụ na-arịwanye elu maka nje bacteria dị ka Staphylococcus Aureus na Escherichia Coli , n'ihi ya, a na-adọta ha na ntutu, na-ahapụ ọnya ahụ dị ọcha. A na-anwale mmeghachi omume bacterial na mgbatị dị iche iche nke eriri eriri dị iche iche site na nchịkọta nke microscopy electron microscopy na confocal microscopy.
A na-adọta nje bacteria ahụ kpọmkwem nke yiri ihe yiri nke ha. Nsonaazụ, nke a na-ebipụta na ACS Applied Materials na Interfaces , na-egosi na electrospinning nanofibers nwere ike ịbụ ụzọ ọhụrụ ịchịkwa ọnyá ndị bacteria na-ebute. Ka ọ dị ugbu a, ndị ọkà mmụta sayensị emeela nanị nyocha na nyocha na anụ ahụ-site na ụdị akpụkpọ anụ. Otú ọ dị, a na-atụ anya na n'oge na-adịghị anya, a ga-eme nyocha ndị yiri ya na anụ ahụ dị ndụ iji nyochaa ikike nke ụzọ ọhụrụ a. A na-eme ihe ọmụmụ ihe omimi na ụfọdụ ụdị ntanopụ nke nanoparticle, dịka ọmụmaatụ, ọlaọcha nanoparticles nwere ihe ịga nke ọma.
> Isi mmalite:
> Abrigo M, Kingshott P, McArthur S. Electrospun polystyrene fiber daylight influencing bacterial attachment, proliferation, na uto. Ihe a na-eme na ACS , 2015; 7 (14): 7644-7652.
> Fredman G, Spolitu S, Perretti M, et al. Ndabere nanoparticles nke nwere peptide acho na-acho ac2-26 na-echebe megide elu atherosclerosis na oke ụmụ oke na hypercholesterolemic. Science Translational Medicine , 2015; 7 (275).
> Leoni G, Neumann P, Reutelingsperger C, et al. Annexin A1 nke na-enwe ihe omumu extracellular vesicles na polymeric nanoparticles na-akwalite mmebi nsogbu epithelial. Journal of Clinical Investigation , 2015; 125 (3): 1215-1227.
> McMasters J, Panitch A. Ogologo oge n'ogologo: Collagen-binding nanoparticles for extracellular anti-inflammatory peptide delivery redulet platelet activation, na-akwalite mwepụ nke endothelial, na-egbochi mbufụt. Nhazi Biomaterialia , 2017; 49: 78-88.
> Zhang M, Viennois E, Merlin D, et al. Ihe nchoputa nke nwere nickel: Nke a bu ihe omimi nke ogwugwu maka mgbochi na oria nke oria ogwu na mkpesa na oria cancer. Biomaterials , 2016; 101: 321-340.