Gaa na Onye Gastroenterologist Gị Tupu I Were Ihe Mgbu
Lelee anya n'obere ụlọ ọgwụ ọbụla ma ị ga-ahụ NSAID (ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ). NSAIDs, bụ ndị a na-eji agwọ ọrịa na mbufụt, bụ ihe a na-ahụkarị na ha na-enwekarị ebe ha na-ere ọgwụ. N'ezie, ọ dị mkpa iji nlezianya mee ka ndị mmadụ ghara ibute ọtụtụ NSAIDS, karịsịa n'ihi na ọ nwere ike ịdị mfe iji ihe karịrị otu n'ime ọgwụ ndị a na-aṅụbigaghị ókè iji mee ihe mgbu na ahụ ọkụ site na flu ma ọ bụ ndị ọzọ ọrịa.
Uzo ozo nke NSAID gụnyere agunye isi ogwu, ihe mgbu mgbu, n 'ugwo anya nke ndi mmadu ma na-edozi nsogbu na ihe mgbu kwa ubochi.
Ndị nwere ọrịa obi na-efe efe (IBD) nwere ahụhụ na ihe mgbu dịka onye ọ bụla ọzọ. Ọtụtụ ndị na-enwekwa ihe mgbu kwa ụbọchị n'ihi ụbụrụ na-agbakwasị ụkwụ-dị ka ọrịa ogbu na nkwonkwo ma ọ bụ site na mmetụta ọgwụ ọjọọ dị iche iche site n'ịgwọ agwọ isi. Otú ọ dị, ụfọdụ ndị gastroenterologists na- atụ aro na ndị ọrịa IBD na-ahapụ NSAIDs. Ihe mere: NSAID nwere ike inwe mmetụta dị njọ na ọrịa Crohn na ulcerative colitis.
Olee otú NSAIDs na-arụ ọrụ
NSAID na-arụ ọrụ site na igbochi abụọ enzymes dị na ahụ: cyclooxygenase-1 (COX-1) na cyclooxygenase-2 (COX-2) . COX-1 na-ekere òkè na usoro nchịkwa na COX-2 na-ekere òkè na usoro mkpesa. Ọrụ nke COX-1 bụ iji dozie ihe ndị a na-akpọ prostaglandins nke na-egbochi imechi afọ site na mmiri ọgwụ nke na-enyere aka nri nri.
Ụbụrụ prostaglandins nke a na-emepụta site na COX-2 na-etinye usoro mkpali na mmeghachi ahụ mgbu.
Ihe nke a pụtara bụ na ọ bụ ezie na NSAID na-eme ka okpukpu ahụ nke mgbu na ihe mgbu dampen, ha na-emekwa ka usoro nchịkwa ahụ kwụsị ụfọdụ n'ime ihe nchebe ya. Nke a nwere ike ịmepụta nsogbu ndị ọzọ maka ndị nwere mbufụt, ma ọ bụ ikike ịmịnye, na tract ha.
NSAIDs na ọnya
Ọbụna na ndị na-enweghị IBD, NSAID nwere ike inye aka na ọnya na afọ ma akụkụ mbụ nke eriri afọ ( duodenum ). NSAIDs nwere ike ime ka mmerụ na-arịwanye elu na obere eriri afọ. Ụfọdụ ndị ọkachamara na-eri nri na-echegbu onwe ha na NSAID nwere ike ime ka IBD pụta na mgbapụta .
NSAIDs na IBD
Nnyocha ma ma NSAID na-enye aka na mgbaàmà IBD bụ esemokwu, na-eme ka esemokwu dị na ha na-eme ihe n'etiti ndị ọkachamara n'ọrịa. Maka otu ọgwụ ndị a na-akpọ COX-2 inhibitors, ugbu a abụghị ọtụtụ ihe àmà na mmetụta ya na ndị nwere IBD. Ụfọdụ nnyocha na-egosi na NSAIDs nwere ike imetụta nanị pasent ụfọdụ nke ndị nwere IBD, mana ọ gaghị ekwe omume ịmata onye ga-emetụta ma ọ bụ na ọ bụghị. E kwuola na iji onye na-emepụta COX-2, kama ọgwụ nke bụ COX-1 na onye na-emepụta COX-2, nwere ike iji nlezianya mee ihe na ndị IBD nọ na nkwụsị.
Ndị nwere IBD kwesịrị ịgakwuru onye na-agwọ ọrịa ha tupu ha ewere NSAID, ọbụna ndị dị na counter. Ọ dịkwa oké mkpa ka ndị niile so n'òtù ahụ ike ahụike mara mmetụta NSAIDs nwere ike inwe na IBD ha.
Ihe Ndị Nwere ike Ime
Ndị nwere IBD bụ ndị na-achọ maka ihe mgbu na-egbuke egbuke nwere ike ịchọrọ ịchọta ihe.
Ekere, nke a na-ere n'okpuru otutu aha, gụnyere Tylenol, abụghị NSAID ma bụrụ nke kachasị mma maka ndị nwere IBD ndị chọrọ enyemaka mgbu. Ot'u acetaminophen si eme ihe iji gbochi ihe mgbu abughi ihe aghotara ya, mana echere na ya ga-akwusi mmebi nke prostaglandins.
Na-atụle mgbe niile na mgbakwunye nke ọgwụ ọgwụ ọhụrụ, karịsịa ndị na-ejikwa jikwaa mgbu. Ọ bụghị onye ọkachamara ahụike ọ bụla nwere ike ịchọta njikọ dị n'etiti painkillers na IBD. Mgbe ndị mmadụ na IBD ga-amalite ịwa ahụ ma ọ bụ usoro, ọ dị mkpa ka ị kwụsị onye gastroenterologist maka nkwurịta okwu banyere ihe ngbu mgbu iji jide n'aka na ị nwere ozi kachasị ọhụrụ banyere NSAID na otu ha si emetụta gị.
N'okpuru ebe a bụ tebụl nke NSAID dị site na ndenye ọgwụ ma ọ bụ n'elu counter. Nke a abụghị ndepụta zuru ezu, biko biko gwa onye na-ere ọgwụ ma ọ bụ dọkịta maka nchegbu gbasara ọgwụ ọjọọ.
Ngwá ọgwụ na-adịghị na steroidal Anti-Inflammatory Drugs (NSAIDs)
| Aha aha | Aha njirimara |
| Advil, Ex, IB, Genpril, Haltran, Ibuprin, Ibuprohm, Ibu-Tab, Midrin 200, Medipren, Midol IB, Motrin, Nuprin, Pamprin-IB, Rufen, Trendar | Ibuprofen |
| Aleve, Anaprox, Naprosyn | Naproxen Sodium |
| Amigesic, Anaflex 750, Marthritic, Mono-Gesic, Salflex, Salsitab, Disalcid | Salsalate |
| Anacin, Bayer, Bufferin, Ecotrin | Choicy salicylate |
| Ansaid, Froben | Flurbiprofen Oral |
| Apo-Keto, Orudis, Oruvail, Rhodis | Ketoprofen |
| Apo-Sulin, Clinoril, Novo-Sundac | Sulindac |
| Aspergum, Ezigbo Bayer, Bayer Childrens, Bufferin, Easprin, Ecotrin, Empirin, Genprin, Halfprin, Magnaprin, ZORprin | Aspirin |
| Maazolidin | Phenylbutazone |
| Cataflam, Voltaren | Nhazi System |
| DayPro | Oxaprozin |
| Dolobid | Ezigbo |
| Feldene, Novo-Pirocam, Nu-Pirox | Na-atụ egwu |
| Indocin SR, Indocid, Novo-Methacin | Indomethacin |
| Lodine | Etodolac |
| Meclomen | Meclofenamate Sodium |
| Mobic | Meloxicam |
| Nalfon | Fenoprofen Calcium |
| Ponstan, Ponstel | Meclofenamic acid |
| Relafen | Nabumetone |
| Inlectin | Tolmetin Sodium |
Isi mmalite:
Kefalakes H, Stylianides TJ, Amanakis G, Kolios G. "Ọhụụ nke ọrịa obi na-efe efe na-ejikọta ya na iji ọgwụ ọjọọ eme ihe na-adịghị mma: akụkọ ụgha ma ọ bụ eziokwu?" Eur J Clin Pharmacol . 2009 Ọkt; 65: 963-970.
Long MD, Kappelman MD, Martin CF, et al. "Ọrụ nke ọgwụ ndị na-emegide ọrịa anti-inflammatory na-abụghịsteroidal na Exacerbations of Inflammatory Bowel Disease." J Clin Gastroenterol . 2016 Feb, 50: 152-156.
Mahadevan U, Emmanuel JJ, Luma Tremaine, WJ. "Nchedo nke Cyclooxygenase-Họrọ 2 Ndị na-emechi ihe na Inflammatory Bowel Ọrịa." Am J Gastroenterol 2002, 97: 910-914.
Matuk R, Crawford J, Abreu MT, et al. "Ụdị dị iche iche nke nsị na ụmịrinụ nke na-egbuke egbuke na mmetụta na-akpata ọrịa nke ịhọrọ cyclooxygenase-2 inhibitors na ndị ọrịa na-arịa ọrịa obi mgbali." Inflam Bowel Dis 2004 Jul; 10: 352-356.
Ribaldone DG, Fagoonee S, Astegiano M, et al. "Nchebe Coxib na ndị ọrịa nwere ọrịa inflammatory ọrịa: Meta-analysis." Ọgwụ Ọrịa . 2015 Nov; 18: 599-607.
Wrena, Wenson, Stenson WF, Brynskov J, et al. "Nchedo nke Celecoxib na Ndị Ọrịa Na-ahụ Maka Ọrịa Ulcerative na Ntugharị: A Na-amụba, Na-achịkwa Control, Nyocha Ọmụma." Clin Gastroenterol Hepatol 2006 Feb; 4: 203-2011.
Singh S, Graff LA, Bernstein CN. "Ndi NSAID, Njegide Ogwu, oria, ma obu Nchegbu Na - adi Na - achoputa na IBD?" Am J Gastroenterol 2009; 104: 1298-1313; bipụtara online 31 March 2009.
Takeuchi K, Smale S, Ndị ahịa P, et al. "Ọdịbendị na usoro nke ọgwụ ndị na-adịghị egbochi ọgwụ ọjọọ na-eme ka ndị mmadụ ghara ịmịnye ọgwụ ọjọọ." Clin Gastroenterol Hepatol . 2006 Feb; 4: 196-202.