Ọrịa Rituxan na Multifocal Leukoencephalopathy

Ọrịa Ogbu na nkwonkwo nke Rheumatoid na Rituxan ọmụmụ malitere PML

A chọpụtala ụdị ọnyá nke PML (mmụba na-arịwanye elu na leukoencephalopathy) na ọrịa ogbu na nkwonkwo nke Rheumatoid (RA) bụ onye tinyere aka na ikpe mkpechapụ maka Rituxan (rituximab). N'ihi ya, FDA na onye na-emepụta ọgwụ ọjọọ enyewo ịdọ aka ná ntị ma mee ka Rituxan mezie ozi iji tinye PML.

Kedu PML?

PML na-amarakwa dị ka ọganihu multifocal leukoencephalopathy.

Dị ka ụlọ ọrụ National Institute of Disorders Neurological and Stroke si kwuo, "Ọganihu na-arịwanye elu leukoencephalopathy (PML) na-akpata site na ntinyeghachi nke nje virus na-emekarị n'ime usoro nchegbu nke usoro ndị na-enweghị nsogbu. ihe ka ọtụtụ n'ime ndị mmadụ ma bụrụ ndị na-adịghị njọ ma e wezụga n'etiti ndị nwere nchebe na-enweghị nchebe. "

Enwere Mmasị Banyere Onye Na-enwe Mgbochi Onye Rụpụtara PML?

Onye RA ahụ bu ụzọ mepụta nje virus JC ma mesịa PML. Ọnwụ PML mere ọnwa 18 mgbe onye ọrịa ahụ natara ngwụsị ikpeazụ nke Rituxan na nchọpụta gbasara nchekwa.

Onye RA ahụ mekwara ka ọrịa kansa oropharyngeal ( ọrịa kansa akwara ) ma mesoo ya na chemotherapy na radiation radiation ọnwa 9 tupu enweghi PML. Onye ọrịa ahụ nwere akụkọ nlekọta ahụike dị mgbagwoju anya nke nwere ike inye aka na mmepe nke PML. E wezụga RA, onye ọrịa ahụ nwere ọrịa Sjogren na arụmọrụ na-enweghị ike ịchọta C4.

A na-emeso onye ọrịa ahụ na usoro, steroid, na TNF blocker tupu e mesoo ya na Rituxan. A na-ejikwa Methotrexate na steroid n'oge ememe ọgwụ ememe.

Kedu ihe FDA na-aza maka PML Case?

FDA na-agagharị na ntuziaka na-enye ntụziaka na ịnye ndị ọkachamara ahụ ike na akwụkwọ ozi na ndị mmadụ na ebe nrụọrụ weebụ ya gbasara ọnwu PML.

Gịnị Ka Ndị Ọrịa Kwesịrị Ekwesị na Rituxan Na-eme?

Dị ka mgbe niile, kwurịta nsogbu gị na dọkịta gị. Ndị ọkachamara na-adụ ọdụ na ọ bụrụ na onye ọrịa na-emeso Rituxan amalite mgbaàmà na-adịghị mma - a ga-atụle nkwarụ ya na onye na-adịghị ahụ maka ọrịa, ụbụrụ MRI, na mgbapu lumbar. Ndị ọrịa na-azụlite PML kwesịrị ịkwụsị Rituxan, ikekwe kwụsị ma ọ bụ belata ndị ọzọ immunosuppressants, mgbe ị na-atụle ọgwụ na-emegide nje. Ma, ọ dịghị ọgwụgwọ ọ bụla nwere ike idozi PML ma ọ bụrụ na ọ na-amalite.

_{Isi mmalite:}

_{FDA: Ọganihu nke Ọganihu Na-enwe Ọganihu Leukoencephalopathy na Ndidi Na-enweta Rituximab. Ozi Nduzi Dọkịta . Septemba 11, 2008.}

_{FDA Medwatch. Ozi Nchekwa Ọhụrụ dị mkpa gbasara Ọganihu Multiwecal Leukoencephalopathy na Iji Rituxan. Septemba 11, 2008.}