Juxtapid (lomitapide) bụ ọgwụ e ji mee ihe na - agụnye ọkwa cholesterol zuru ezu, LDL, na apolipoprotein B - yana nri na ọgwụgwọ ndị ọzọ - na ndị mmadụ nwere hyperzylesterolemia homozygous, ọnọdụ na-adịghị ahụkebe, nke na-akpata nnukwu LDL cholesterol ọkwa na ọrịa obi ọrịa n'oge ná ndụ. Juxtapid kwadoro maka iji ọgwụ nri na ọgwụ ọjọọ eme ihe na United States na December 2012.
A na-amụcha naanị Juxtapid na ndị mmadụ chọpụtara na hypercholesterolemia homozygous - na ọ bụghị ndị nwere ọnọdụ ndị ọzọ na-akpata ọkwa cholesterol dị elu. Na otu ọmụmụ, a na-enyefe ndị mmadụ n'otu n'otu na-ewere ọgwụgwọ cholesterol ndị ọzọ na-eme ka ọ dị elu maka ogo ha dị elu karịa LDL cholesterol. Ọmụmụ ihe a gosiri na ịgbakwunye Juxtapid na ọgwụgwọ ndị ọzọ belatara LDL ọkwa site na ruo 50%. A na-ewepụtarịrị ọkwa nke triglyceride, apolipoprotein B ọkwa, VLDL na ọkwa cholesterol niile.
Ọmụmụ ihe ọzọ nyochare irè na nchekwa na ndị nwere otu ahụike ahụ na-ewere Juxtapid nanị ka ọ dị ala ọkwa cholesterol. Ná ngwụcha nke ọmụmụ ihe a, na ihe dịka 1 mg / kg / ụbọchị, LDL ọkwa na apolipoprotein B ọkwa dị ala 50%.
Ọ bụ ezie na nchọpụta ndị a nyere aka belata cholesterol dị ukwuu na ndị ọrịa a, ha egosikwa na Juxtapid nwere ike ịkpata mmetụta dị oke egwu - gụnyere ọrịa na ọrịa imeju.
Tụkwasị na nke a, ebe ọ bụ na ọmụmụ ihe a adịgidere ruo izu iri asaa na asaa, a na-eduzi ọmụmụ ihe ndị ọzọ iji chọpụta nchekwa na ogologo oge nke Juxtapid.
Olee Otú O Si Arụ Ọrụ?
Juxtapid na-ebelata LDL cholesterol site na igbochi protein microsomal triglyceride nyefe (MTTP), nke dị na ahụ nke na-egbochi VLDL na chylomicrons ka ha ghara ime n'ime imeju.
Ebe ọ bụ na VLDL ghọrọ LDL, nke a ga-ebelatakwa LDL ọkwa n'ọbara.
Kedu ka m kwesịrị isi jiri ọgwụ a?
Juxtapid kwesịrị ijide ọnụ, ya na iko mmiri, na afo efu. A na-atụ aro ka a ṅụọ ọgwụ ahụ ma ọ dịkarịa ala awa abụọ mgbe nri abalị gasịrị. Onye na-ahụ maka ahụike gị ga-agba mbọ ịnwale ọbara - gụnyere ịchọta enzymes imeju na ọkwa cholesterol - tupu ịdee Juxtapid ka ọ bụrụ gị.
Ihe Ndi Nwere Ike Ime
Enzymes imeju na ume na nnukwu abụba n'ime imeju na-ejikọta aka na Juxtapid. Ya mere, dọkịta gị ga-achọ ịnwale ọbara ọbara oge iji chọpụta ọnọdụ imeju nke imeju gị, nke gụnyere alanine aminotransferases, aspartate aminotransferases, na alkaline phosphatase, na mgbakwunye na nlekota ọkwa gị cholesterol. N'ihi mmetụta ndị a, Juxtapid na-ebu "ịdọ aka ná ntị ojii" maka hepatotoxicity, nke bụ ịdọ aka ná ntị siri ike nke Food and Drug Administration nyere maka eziokwu ahụ bụ na e gosipụtawo akụkụ a n'ọmụmụ ihe nke na-enyocha nchekwa ọgwụ ahụ. N'ihi mmetụta nwere ike ịba uru Juxtapid nwere na imeju, onye dọkịta gị ga - edebanye aha gị na usoro mgbochi, nke a na - akpọ programmụ JMStapid REMS.
N'okpuru usoro ihe a, naanị ndị dọkịta na ndị ọkachamara na-ekwenye na nghọta na ọgwụ na ihe ize ndụ ya nwere ike ịkọ ma kesaa Juxtapid.
Mmetụta mmetụta ụbụrụ, dịka ọgbụgbọ, vomiting, nrịkasi obi, afọ ọsịsa, afọ ntachi na abọma nke abdominal, abụwo mmetụta kachasị emetụta ndị mmadụ na-ewere Juxtapid. Ụfọdụ ndị mmadụ ekwupụtakwala na ha na-enwe mmetụta dị arọ, obi mgbu obi, na ike ọgwụgwụ mgbe ị na-aṅụ ọgwụ.
Ònye Kwesịrị Iwere Ya?
Ka ọ dị ugbu a, a na-amụrụ naanị Juxtapid na ndị mmadụ na - ahụ maka hyperzylesterolemia homozygous n'ihi na ha nwere nnukwu nsogbu maka ọrịa obi.
Ya mere, a maghị ma ọ bụrụ na Juxtapid dị irè na ndị nwere ọnọdụ ahụike ọzọ na-eme ka ọkwa cholesterol dị elu. Ndị ọzọ ndị kwesịrị ịjụ dọkịta ha tupu ha ewere Juxtapid gụnyere:
- Ndị nwere ọrịa imeju - Juxtapid nwere ike ịmalite imeju enzymes imeju dị ka transaminases na imeju abụba.
- Ndị nwere ọrịa akụrụ - Ụdị Juxtapid nwere ike ịbawanye n'ọbara.
- Ụmụ nwanyị ndị dị ime - E gosipụtara na Juxtapid dị njọ nye nwa ebu n'afọ na ọmụmụ ụmụ anụmanụ. Ụmụ nwanyị nwere ike ịmịgharị ga-achọ ịnwale ule ime nwa na-ezighị ezi tupu ịmalite Juxtapid ma nwee ike iji ụdị ụfọdụ nke akara ịmụ nwa dị irè mgbe ị na-aṅụ ọgwụ ahụ.
- Ụmụ nwanyị na-elekọta nwa - Juxtapid agụghị ọtụtụ akwụkwọ. N'ihi na enwere ike ịzụlite ụbụrụ na ụmụ oke, a na-atụ aro ka a kwụsịrị ịzụ nwa - ma ọ bụ ọgwụ ọjọọ.
Mmekọrịta ọgwụ ọjọọ
E nwere ọgwụ ụfọdụ nwere ike iji Juxtapid meekọrịta ihe, nke nwere ike ime ka ị na-emetụta ịta Juxtapid ma ọ bụ ọgwụ ndị ọzọ na ahụ. Ndị na-esonụ bụ ndepụta nchịkọta nke ọgwụ ndị nwere ike iji Juxtapid mee ihe ma ọ bụrụ na ị na-ewere otu ma ọ bụ karịa n'ime ọgwụ ndị a, ị ga-ahụ dọkịta gị.
- Vitamin A, D, E, na K, na omega-3 acid fatty soluble , nwere ike ọ gaghị etinye obi gị dum mgbe ị na-ewere Juxtapid.
- Juxtapid nwere ike ime ka ọbara dịkwuo ụfọdụ ọbara , dịka warfarin, n'ọbara. Nke a nwere ike ime ka ị na-agba ọbara ma ọ bụ na-emerụ ahụ.
- Ọ bụrụ na ị na-ewere atorvastatin ma ọ bụ simvastatin, Juxtapid nwere ike ime ka ọbara dịkwuo oke ọgwụ ndị a. Dọkịta gị nwere ike ịgbanwe usoro ọgwụgwọ gị mgbe ị na-ewere Juxtapid.
N'ihi ụzọ Juxtapid si emetụta ahụ ya, ọ nwere ike ime ka ọbara dịkwuo n'ọtụtụ ọgwụ ndị ọzọ ị na-ewere - ya mere ị na-eme ka ọgwụ dịkwuo njọ. Ndị a na-agụnye ụfọdụ ọgwụ ọjọọ, ọgwụ nje, ọgwụ nje nje, ọgwụ ọbara ọbara, ọgwụ ndị a na-eji agwọ ọrịa, na ihe ndị sitere n'okike (dịka goldenseal, grapefruit). Ya mere, ị ga-ahapụrịrị ndị na-ahụ maka ahụike gị gbasara ọgwụ ọ bụla ị na-aṅụ ka ha wee nwee ike ilebara anya maka mmekọrịta gị na Juxtapid. Dọkịta gị nwere ike ikpebi ịgbanwe usoro ọgwụ gị nke Juxtapid ma ọ bụ ọgwụ ndị ọzọ ma ọ bụrụ na achọpụta mmekọrịta.
Ndabere ala
Juxtapid bụ ọgwụ mbụ cholesterol-ịdọrọ ala nke anakwere na inhibits MTTP. Ọ bụ ezie na nchọpụta egosiwo na Juxtapid na-agbakwunyekwuo LDL-ike ịba ụba n'ime ndị nwere ezinụlọ homozygous hypercholesterolemia, enwere ọtụtụ nsogbu nchedo Juxtapid na ojiji ya ejirila ọnọdụ ọrịa a kpọmkwem n'ihi nsogbu ndị a. Dibịa gi ga-enyocha abamuru nke iwere Juxtapid, tinyere ihe ize ndụ nke inwe nsogbu uto na ọgwụ. Ebe ọ bụ na amataghi na-ejiri Juxtapid amaghị - gụnyere ike igbochi ọrịa obi - enwere ihe ọmụmụ na-aga n'ihu iji nyochaa nke a.
Isi mmalite:
Cuchel M, Meagher EA, Theron HD, et al. Mmetụta na nchekwa nke microsomal triglyceride nyefe protein inhibitor na ọrịa na homozygous ezinụlọ familial hypercholesterolemia: otu ogwe aka, oghe-labeelu, oge 3 ọmụmụ. Lancet 2013; 381 (9860): 40-6.
Cuchel M, Bloedon LT, Szapary PO, et al. Mgbochi nke protein microgenal triglyceride na-ebute protein na hypercholesterolemia ezinụlọ. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (lomitapide) Ngwugwu Tinye. Aegerion Pharmaceuticals. March 2016.