A Corticosteroid a kpụrụ maka Ntọhapụ oge
Rayos ( prednisone ), nke a maara dị ka Lodotra na Europe, bụ usoro mgbasa ozi-oge-azụ nke prednisone dị ala. Rayos, nke Horizon Pharma mere, kwetara na US Food and Drug Administration (FDA) na July 26, 2012, maka ọrịa ogbu na nkwonkwo na ọtụtụ ihe ndị ọzọ.
Nkwado FDA na-adabere na data na-atụle ọgwụcokinetics (ya bụ, esi etinye ọgwụ ahụ, metabolized, eliminated) nke Rayos na ozugbo-hapụ prednisone, yana data si n'aka Circadian Administration nke Prednisone na RA (CAPRA-1 na 2 ) ule.
CAPRA-2 kpughere na ndị nwere ọrịa arthritis siri ike bụ ndị a na-emeso Rayos nwere ọganihu dị ịrịba ama na ntinye nzaghachi ACR20 tụnyere placebo, yana ọganihu dị ukwuu na ọkwa ike. CAPRA-1 nyochara nchekwa nke Rayos.
Ntu
Rayos bụ corticosteroid na-eme ihe na-adịghị mma ma ọ bụ nsogbu immunosuppressive na-eji agwọ ọrịa, dermatologic, endocrine, eriri afọ, hematologic, neoplastic, usoro ụjọ, ophthalmologic, renal, respiratory, and rheumatologic conditions.
N'ihe banyere ọnọdụ nrịanrịa, a pụrụ iji Rayos mee ihe maka enyemaka dị mkpirikpi maka nnukwu ọrịa nke arthritis. A pụkwara iji Rayos mee ihe n'ọnọdụ ụfọdụ nke sparkylitis ankylosing , dermatomyositis, polymyositis, polymyalgia rheumatica , arthritis psoriatic , nlọghachite polychondritis, ọrịa ogbu na nkwonkwo, ọrịa Sjogren , lupus erythematosus , na vasculitis .
Nnweta
Rayos dị dị ka 1 mg., 2 mg., Na 5 mg. egbu oge-ntọhapụ mbadamba.
Akwụsị
A ghaghị ichebara ihe dị iche iche echiche n'otu n'otu maka ọrịa siri ike na ma ndị ọrịa na-eji ozugbo prednisone. Nri mbụ bụkarị 5 mg. nke Rayos otu ugboro n'ụbọchị. Otú ọ dị, ndị ọrịa ugbu a na prednisone nwere ike ịchọ nhazi ịhazi iji mee ka ọ bụrụ otu mgbe ị gbanwere Rayos.
A ghaghị iji mmiri rie nri, ma mbadamba nkume ahụ ga-ewecha. Maka nkwado, a ghaghị iji ọgwụ kachasị dị irè mee ihe. Mbelata akara kwesịrị ịdị nwayọọ.
Mmeghachi omume na-adịghị mma
Mmeghachi omume ọjọọ kachasị emetụta nke corticosteroid gụnyere njigide mmiri, ịrị elu n'ọmịnye ọbara, mgbanwe n'ime ndidi glucose, mgbanwe ihu igwe, uru dị arọ, na agụụ na-arịwanye elu.
Enwere mmeghachi omume ndị ọzọ na-adịghị mma bụ ndị ejikọrọ na ọtụtụ akụkụ ahụ nke anụ ahụ. Ozi zuru ezu nke edepụtara maka Rayos nwere ndepụta dị oke. Mmetụta ihe ojoo na-akpata nke nwere ike ịchọta corticosteroid gụnyere osteonecrosis nke ụbụrụ femoral na isi ụbụrụ, osteoporosis , adịghị ike nkwarụ, ọkpụkpụ muscle, mkparịta ụka mkparịta ụka na mkpịsị aka.
Contraindications
Ndị ọrịa nwere ike ghara iji ndị hypersensitivity mara ọkwa na prednisone ma ọ bụ ihe ndị ọzọ na-adịghị arụ ọrụ nke dị na mbadamba.
Ịdọ aka ná ntị
- Ọrịa, karịsịa ndị a na-emeso prednisone maka oge dị ogologo, kwesịrị nyocha maka hypothalamic-pituitary-adrenal axis suppression, Cushing's syndrome, na hyperglycemia.
- Enwere mmetụ dị ukwuu na ọrịa ọhụrụ ma mee ka ohere nke exacerbation ma ọ bụ mmeghachi omume nke ọrịa ndị na-arịa ọrịa na-arịa ọrịa na-arịa ọrịa na-agwọ ọrịa na Rayos ma ọ bụ prednisone.
- Mkpụrụ ọbara, na sodium na potassium ga-elele anya. Ọgwụ nwere ike imetụta nnu na njigide mmiri.
- Enwere nsogbu dị ukwuu nke ọrịa nsí, gụnyere nkwụsị. Mgbaàmà nwere ike masked.
- Euphoria, ehighi ura, ngbanwe ọnọdụ uche, mgbanwe ndi mmadu, na nnukwu ịda mbà n'obi nwere ike ime. Enwere ike inwe mmetụta uche nke nwere ike ịdị njọ na iji prednisone.
- Mbelata na njupụta ọkpụkpụ nwere ike ime.
- Enwere ike inwe mmetụta nchịkwa nke gụnyere cataracts, glaucoma, na ọrịa.
- A gaghị etinye ọgwụ ma ọ bụ na-adị ndụ ma ọ bụ na-adị ndụ na-adịgide adịgide nye ndị ọrịa na-ewere ọgwụ immunosuppressive nke prednisone.
- Nsogbu nwa ebu n'afọ nwere ike ime n'oge mbụ nke afọ atọ nke ime ime.
Mmekọrịta ọgwụ ọjọọ
Rayos nwere ike imekọrịta na:
- Ndị anwụrụ
- Ọrịa na-emegide ọrịa shuga
- CYP3A4 inducers na ndị na-emechi ihe
- Cyclosporine
- NSAIDs (ọgwụ ndị na-adịghị egbochi ndị na-egbu egbu)
Jide n'aka na dọkịta gị maara ụdị ọgwụ niile na ihe mgbakwunye ị na-ewere ugbu a. Ọ dị mkpa ịtụle ihe ize ndụ nwere ike ịba uru nke ọgwụgwọ na Rayos.
Kedu ihe dị iche?
Kedu ka Rayos si dị iche na ntọhapụ prednisone ozugbo? N'ọnwa ahụ, Rayos nọ na-elekọta ya n'elekere 10 nke ụtụtụ na nri. Ngalaba a na-egbu oge nke Rayos kwere ka usoro ọgwụgwọ nke prednisone na ọbara mepụta mgbe usoro cytokine malitere ịbawanye n'etiti abalị. Usoro a nke ime ihe nwere ike inye aka ka ọ ghara ịmị n'ahụ ụfọdụ ndị ọrịa.
Isi ihe
Rayos. Na-edepụta Ozi.
http://www.rayosrx.com/PI/RAYOS-Prescribing-Information.pdf
Horizon Pharma na-ekwupụta FDA nkwado nke RAYOS® (prednisone) Ntọala-Ntọhapụ Mbadamba maka Arthritis Rheumatoid na Ọtụtụ Nkọwa Ndị Ọzọ. Horizon ahịa. July 2012.
http://ir.horizon-pharma.com/releasedetail.cfm?ReleaseID=695983