Benfotiamine bụ ụdị mmadụ nke thiamine ma ọ bụ B1. Thiamine bụ mmiri vitamin soluble na ya mere ọ bụghị dị ka ọ dị mfe na-eji ahụ. Benfotiamine bụ ihe na-edozi ahụ ma bụrụ nke edozila ma tinye ya n'ọrụ. Enweela ihe ụfọdụ na-egosi na benfotiamine nwere ike inye aka belata ịdị njọ nke ọrịa shuga dị ka retinopathy, nephropathy, na nkwụsị.
Benfotiamine maka ọrịa ọrịa Neuropathy
Benfotiamine emeela ọtụtụ ọmụmụ na afọ ndị a. Ihe nlebara anya nke ọmụmụ a gụnyere iji benfotiamine dịka ọgwụgwọ maka nsogbu nke ọrịa shuga.
Ihe ka ọtụtụ nsogbu ndị ọrịa shuga na-akpata site na hyperglycemia ogologo (ọbara ọbara dị elu) n'ihi ọbara glucose a na-achịkwa ma ọ bụ ọrịa na-agafe oge. A na-etinye glucose dị n'ime ọbara na mkpụrụ ndụ nerve na obere arịa ọbara nke ngwụsị, na-eme ka mmebi na mpaghara ndị a na-eme ka ihe ịrịba ama na mgbaàmà nke nsogbu dị.
Ụzọ Ụzọ Atọ Na - akpata Mmebi Cellular
Enwere ụzọ ụzọ anọ dị iche iche nke na-eme n'ime ahụ nke nwere ike iduga nbibi nke obere ọbara n'ihi ọrịa hyperglycemia na ọrịa shuga.
- Ihe nkwụsịtụ dị elu glycation (AGE)
- Protein kinase C (PKC)
- Hexosamine ụzọ nbanye
- Polyol ụzọ mmalite
Benfotiamine yiri ka ọ na-egbochi ụzọ atọ n'ime ụzọ ndị a na ọmụmụ ihe. Otu akwụkwọ, nke pụtara na magazin Nature Medicine na February 2003, nke a kpọrọ "Mgbochi Benfotiamine Ụzọ atọ kachasị njọ nke emerụ ahụ na-egbochi ahụmahụ ọrịa shuga" bụ nke gosiri na benfotiamine gbochiri ịrịa ọrịa cancer na ịme anụ ụlọ.
Ogologo Glycation End Ngwaahịa
Hyperglycemia na-akpata mmerụ n'ime arịa ọbara na ahụike nke ahụ, nke na-eme ka ọ ghọọ nsogbu kachasị njọ nke ọrịa shuga. Mmebi na-eme mgbe ntụtụ glucose n'ime ọbara na-abanye na mkpụrụ ndụ ma na-emepụta ihe a maara dị ka ihe ndị na-eme ka ọsịgwụ glycation (AGE) ha na-agbakọta n'oge. A na - achọta ihe dị na arịa nke anya, akụrụ, na njedebe. A na-ahụkwa ha na arịa ndị ọzọ bụ isi na-eduga na nchịkọta akara na atherosclerosis, na-enye aka na ọrịa obi.
Gịnị Benfotiamine Na-eme
Nnyocha e mere egosiwo na benfotiamine yiri ka ọ na-egbochi igbochi ọrịa neuropathy, retinopathy, na nephropathy site na-egbochi mgbidi glucose n'ime arịa. Nke a pụtara na nsogbu nke ọrịa shuga nwere ike ịme ngwa ma ọ bụ gbochie. Nnyocha ọmụmụ nke pụtara na ADA Journal Diabetes n'afọ 2003 gosiri na thiamine na benfotiamine dị elu yiri ka ọ na-egbochi microalbuminuria na proteinuria (protein na urine) n'ime oke bekee ọrịa shuga. Nnyocha e mere na ndị mmadụ egosiwo na benfotiamine na-egosikwa na ọ na-egbochi nhụjuanya neuropathic.
Ọnọdụ dị ugbu a nke Benfotiamine
Benfotiamine ka na-enwe usoro ikpe na-adakarị. A na-emekarị ihe ọmụmụ a na oke ndị e dinara ka ha nwee ọrịa shuga.
A ghaghị ịnwa ule kpụ ọkụ n'ọnụ karị iji chọpụta ma ọ bụrụ na benfotiamine na-arụ ọrụ otu ụzọ ahụ na ndị nwere ọrịa shuga. Enweghi ike idozi ọgwụ ndị dị irè, a chọpụtakwara mmetụta ndị dị ogologo oge.
Ọ bụ ezie na ndị ọkachamara ahụike nke American na-akwado benfotiamine n'oge a, ọ dị ka ọ nwere ike ịbụ ọgwụgwọ na-ekwe nkwa maka nsogbu ọrịa shuga na-aga n'okporo ụzọ.
Nkwado ka na-echere site na FDA
Nchịkwa nri na ọgwụ ọjọọ (FDA) anabatabeghị benfotiamine maka iji ọha na eze mee ihe. E nwere esemokwu banyere etu a ga - esi kpọọ ya, ma ọ bụ dị ka ihe oriri ma ọ bụ vitamin.
Enwere nchegbu banyere nchekwa zuru ezu nke iji ogologo oge mee ihe nke benfotiamine na ihe dị na usoro ọgwụ dị mma. FDA chọrọ ihe akaebe ọzọ na benfotiamine na-arụpụta ihe ndị a hụrụ n'ime ule.
N'afọ gara aga, e debere benfotiamine na FDA dị ka mgbakwunye nri, ma ihu ọma na-echere na oge a.
- FDA Response Letter to Submission of Benfotiamine dị ka ihe oriri Dietary
Isi mmalite:
> Haupt, E., Lederman H., Kopcke W. "Benfotiamine na-agwọ Ọrịa Polyneuropathy - Ọhụụ Izu atọ, nke Ọmụmụ Ihe Ọchịchị Na-achịkwa." International Journal of Clinical Pharmacology, Therapy and Toxicology Jun 2005: 304. PubMed.gov. National Library of Medicine na National Institute of Health. 09 Mar 2007.
> Huebschmann, MD, Amy G., Regensteiner, Ph.D., Judith G., Vlassara, MD, Helen, na Reusch, MD, Jane EB "Ọrịa shuga na Ọganihu Glycoxidation End-Ngwaahịa." Diabetes Care 2006 1420-1432. 09 Mar 2007.
> Melpomemi >, MD, Peppa, Uribarri, MD, Jaime, na Vlassara, MD, Helen. "Glucose, Ọganihu Ọgwụgwụ Ngwaahịa, na Ọrịa Shuga Ọdachi: Ihe Dị Ọhụrụ na Ihe Na-arụ." Ọrịa Ọrịa Clinical 2003 186-187. 09 Mar 2007.
> Stirban, MD, Alin, Negrean, MD, Monica, Stratmann, > PHD >, Bernd, Gawlowski, MS, Thomas, Horstmann, Tina, > Gotting >, > PHD >, Christian, Kleesiek, MD, Knut, Mueller-Roesel , MD, Michaela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, Helen na Tschoepe, MD, Diethelm, "Benfotiamine Na-egbochi Macro- na Microvascular Endothelial Dysfunction na Oxidative Nchegbu na-eso a nri ọgaranya na Advanced Glycation Ọgwụgwụ Ngwaahịa n'ime ndị nwere ụdị ọrịa shuga nke abụọ. " Ọrịa shuga na-elekọta 2006 2064-2071. 13 Mar 2007.
> "Ọgwụ Ọjọọ Iji Nagide Nsogbu." Site na Nnyocha na Eziokwu. 2005. Nchọpụta Nchọpụta Maka Ọrịa Ọrịa Shuga nke Mba. 18 Mar 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "Ngalaba Benfotiamine Ụzọ atọ kachasị njọ nke mebiri emebi na ịgbochi Ọrịa ọrịa shuga." Medicine Nature, 18 Feb 2003 294-299. 18 Mar 2007.