Kedu ihe bụ Ọhụrụ na Ngwọta Ọrịa Cancer?

Ngwọta maka ọrịa cancer prostate na-eguzogide ọgwụ

Ọtụtụ ihe gbanwere n'ọgwụgwọ ọrịa cancer prostate n'ime afọ ole na ole gara aga. Nke a bụ eziokwu karịsịa maka ọgwụgwọ cancer cancer prostate nke metastatic (mCRPC). Nke a bụ ọrịa cancer prostate nke na-adabaghị ọgwụgwọ bụ isi (ịwa ahụ, radiation etc.) ma gbalịsie ike ịgwọ ọgwụgwọ homonụ (androgen blockade or castration).

Nke a na-emetụta ndị ọrịa ndị na-arịa ọrịa metastatic ma mebie ọgwụgwọ nke ọgwụgwọ. Tupu mmalite nke iji chemotherapy maka ndị ọrịa a, oge ndụ n'ogologo dị ihe dịka ọnwa 8. Chemotherapy mma na nke a kama ọ bụghị ọgwụgwọ.

Kemgbe 2010, ọtụtụ ọgwụgwọ ọhụrụ aghọwo ndị ọrịa nwere mCRPC. Ndị na-esonụ bụ nkọwa nkowa nke ọgwụgwọ kachasị ọhụrụ.

1. Abiraterone Acetate (Zytiga) - Zytiga na-egbochi mmepụta nke protosterone precursors ma belata ọkwa nke testosterone. A na-enyekarị ya prednisone. Zytiga bụ ndị e gosipụtara na ndị ọrịa bụ ndị na-emeghị docetaxel (chemotherapy) mana nchọpụta ndị na-adịbeghị anya egosipụtara uru na onye ọrịa na-ebute ọrịa. Otu nnyocha gosiri na ngbapụta redial nke na-aga n'ihu (rpFS) bụ ihe karịrị ọnwa 16 na ndị Abiraterone na ndị prnisone nke ruru ọnwa asatọ na njikwa ahụ.
2. Enzalutamide (Xtandi) - Nke a maara dị ka MDV3100 ọgwụ a bụ ọgbọ nke abụọ androgen-receptor. Ọ na-arụ ọrụ ma n'èzí na n'ime sel. E gosipụtara ya na mbụ na ndị ọrịa na-ebute ọrịa chemotherapy maka mCRPC ma nchọpụta egosiwo uru na onye ọrịa na-ebute ọrịa chemotherapy. Nyocha ọmụmụ PREVAIL gosipụtara na, ná nkezi, enzalutamide egbughị oge ọ dị mkpa iji chemotherapy site na ọnwa 17 (28 na 11). O gosiputara na ojiji nke usoro ọgwụ redio a na-egbu oge na pasent 81%.

1. Radium 223 Dichloride (Xofigo) - Ọ bụ ezie na nke a bụ ọgwụ ogwuzi bụ ụdị radiation a na-akpọ red radiation. A na-eme ọgwụgwọ a iji gbochie mkpụrụ ndụ cancer cancer na ọkpụkpụ. Ọkpụkpụ nwere ọrịa kansa prostate na-etinye aka na Xofigo. Radium na - ewepụta radial radiation, bụ nke dị mkpirikpi. Ebumnuche bụ igbu mkpụrụ ndụ cancer nke na-arịa ọrịa na-enweghị obere mmebi nke ọkpụkpụ nkịtị. Nke a ga-abụ ihe a na-eche karịa strontium-89, nke e jirila n'oge gara aga. Nnyocha egosiwo ọganihu dị ukwuu na ndị nwere ọrịa mCRPC na ọkpụkpụ.

1. Sipuleucel-T (Provenge) - Sipuleucel-T bụ ọgwụ ogwu cancer maka ọgwụ cancer. A na-ebute ya maka ndị ọrịa na-ahụ maka mymPC ma ọ bụ ndị na-egosi na ọ bụ obere ihe. A na-ele onye ọ bụla anya na onye ọ bụla na-achọ enyemaka ọbara. A na-arụ ọrụ ọbara na ụlọ nyocha ma weghachite ya ọzọ n'izu. A na-enye ọgwụgwọ ugboro atọ karịa oge nke otu ọnwa. Ọ bụ ọgwụ MDA mbụ nwere ike ịgwọ ọrịa cancer (dịka ogwu ọgwụ gbochie). A mụbara ọhụụ n'ozuzu site na iji Provenge na-egosi ọrịa ma ọ bụ ndị ọrịa mCRPC dị ntakịrị.

Ajụjụ ndị nwere olileanya na a ga-akọwa n'ọdịnihu bụ otu kachasị mma usoro ọgwụgwọ ndị a? Mgbe onye ọrịa na-adaba na hormones, olee ọgwụ a ga-eji mee ihe mbụ ma ọ bụ na a ga-amalite chemo? Kedu ọgwụ na-enye uru kacha mma? Ekwesịrị iji ọgwụ ndị a mee ihe ma ọ bụ na ọnụ? Ọ bụ ezie na ọtụtụ ajụjụ dị ịrịba ama na mgbakwunye ndị a na-adịbeghị anya na ngwá agha cancer prostate ga-abara ọtụtụ ndị ọrịa uru.

_{Isi ihe}

_{Rathkopf DE, Smith MR, De Bono JS, et al. Nyocha oge mkparịta ụka (IA) nke COU-AA-302, ọmụmụ nke atọ nke III nke acbiraterone acetate (AA) na ndị ọrịa (pts) na cancer cancer prostate na-eguzogide metastatic (mCRPC) n'emebughị ọgwụgwọ. J Clin Oncol. 2013; 31 (seta 6, abstr 5).}

_{Beer TM et. al. Enzalutamide n'ime ụmụ nwoke na-agwọ ọrịa-ọrịa cancer prostate na-adịghị mma (mCRPC): Nsonaazụ nke ọmụmụ phase III PREVAIL. J Clin Oncol 32, 2014 (seta 4; abstr LBA1 ^).}

_{Parker C et al. Alpha Emitter Radium-223 na Ịlanahụ na Ọkụ Ọkụ Metastatic Prostate Cancer. N Engl J Med. 2013; 369: 213.}

_{Longo DL (July 2010). "Ọgwụgwọ ọhụrụ maka cancer cancer prostate". N. Engl. J. Med. 363 (5): 479-81.}