Rheumatoid vasculitis bụ ihe siri ike, nke dị oké njọ nke ọrịa ogbu na nkwonkwo nke nwere ike ịdị ndụ egwu. N'ọbụrụ vasculitis, ọnyá na- agbasa na obere iko ma ọ bụ nke ọkara dị n'ime ahụ. Ọtụtụ mgbe, a na-etinye akwara, ma ọ bụ nke ọma. A naghị enwekarị nnukwu arịa ọbara.
Mgbidi nke arịa ọbara na-agbapụta na-esiwanye ike na dịka lumen nke ọbara ọbara na-emetụta ya, o nwere ike ịbịaru nso.
Enwere ike imebi ọbara na ngwa ahụ, ma ọ bụrụ na ọ bụghị ihe ọ bụla. Rheumatoid vasculitis nwere ike ịgụnye akụkụ ahụ dị iche iche, gụnyere akpụkpọ ahụ, anya, akwara, obi, ọkụ, ụbụrụ, akụrụ, ma ọ bụ akụkụ eriri afọ. Ma, enwerekwa ozi ọma. Ndị ọrịa na-arịa ọrịa ogbu na nkwonkwo na-arịwanye elu nke vascularitis rheumatoid, ma eleghị anya site na ọgwụ ndị ọzọ dị irè bụ ndị mepụtara ma na-ere ahịa na iri gara aga ma ọ bụ ya (ya bụ, ọgwụ ndị dị ndụ ).
Ọdịnihu na oke egwu nke Rheumatoid Vasculitis
Ọ bụ ezie na njupụta nke rheumatoid vasculitis yiri ka ọ na-ebelata, a na-eme atụmatụ na ihe na-erughị otu n'ime pasent 5 nke ọrịa ọrịa ogbu na nkwonkwo na-emepụta rheumatoid vasculitis. Otú ọ dị, nchọpụta ndị na-agụnye akwara na-egosi 15-31%. Mgbaghara na ọnwu ọnụọgụ nke jikọtara na vascularitis rheumatoid dị ịrịba ama na ọnụọgụ afọ 5 na 30-50% na ọbụna oke ọnụọgụ na-emetụta ọrịa nsogbu ma ọ bụ ọgwụgwọ ọrịa.
Ihe ndị na-esonụ na-eme ka ihe ize ndụ nke ịmepụta rheumatoid vasculitis:
- Ezigbo ihe kpatara ihe rheumatoid
- Ezi maka anti-CCP
- Nwoke (1 n'ime ụmụ nwoke 9 nwere ọrịa ogbu na nkwonkwo na-eto eto na-emepụta rheumatoid vasculitis)
- Ịṅụ sịga
- N'ihu nke rheumatoid nodules
- Okenye na ọrịa ma ọ bụ ogologo oge nke ọrịa ogbu na nkwonkwo (ihe karịrị afọ 10)
Mgbaàmà na Ngosipụta nke Vasculitis Rheumatoid
Ọ bụla akụkụ nke ahụ nwere ike emetụta rheumatoid vasculitis. Akpụkpọ anụ na irighiri akwara na-ejikarị eme ihe. Ọ bụ ezie na a na-ewere itinye aka nke akụkụ ahụ dị ka ihe na-adịkarịghị, ọ na-ejikọta ya na ọnwụ na ọnwụ.
Ntinye aka nke anụ nwere ike ịgụnye purpura, nodules, ọnya afọ, na nịrosis nke mkpụrụ, karịsịa mkpịsị aka. Livedo reticularis bụ ihe a na-ahụkarị. Ntinye oku na-etinye oku maka nyochakwu banyere ntinye aka ọzọ. Ọkpụkpụ , pleuritis , ma ọ bụ pericarditis bụ ihe atụ nke ihe nwere ike ịzụlite. Ọ bụrụ na akpụkpọ ahụ na-etinye aka na-enweghị ntinye aka ọzọ, usoro prognosis ka mma.
N'iji usoro nhụjuanya nke akụkụ ụwa, enweghi ike imepụta neuropathies , dị ka ihe mgbagwoju anya nke polyneuropathy, ihe mgbagwoju anya ma ọ bụ jikọtara neuropathy, ma ọ bụ monoperic multiplex. Mgbe vasculitis emebi akwara. enwere ike ịda mbà, nsị, ụfụ, ike, na nkwụsị ọrụ na aka ma ọ bụ ụkwụ. Mgbaàmà ndị ọzọ zuru oke pụkwara ime, dị ka ọkụ, ụkọ ọnwụ, ọnwụ nke agụụ, na ike nke ume.
Nchoputa nke Vasculitis Rheumatoid
Ọ bụ ezie na usoro ihe mgbaàmà nwere ike ime ka dọkịta chee na vascularitis rheumatoid na nyocha ụlọ nyocha nwere ike inye ihe akaebe na-akwado maka nchọpụta ihe yiri nke ahụ, a chọrọ biopsy maka nchọpụta doro anya.
Akpọrọ akpụkpọ nwere ike ịbụ ọrịa ndụ, yana ahụ ike ma ọ bụ akwara n'ime mpaghara emetụta, ma ọ bụ akụkụ ahụ metụtara.
Ọ bụ ezie na a na-ebuli ule ọbara maka ihe ndị na-akpata ọrịa na-emegide CCP bụ ndị dị elu na vasculitis rheumatoid, ihe ndị a apụtaghị kpọmkwem. Mgbochi abụọ ahụ jupụtara n'ọbara ogbu na nkwonkwo na-enweghị vasculitis. Mgbochi nke na-emegide anti-neutrophil cytoplasmic (ANCA) na ọgwụ mieloperoxidase na anti-proteinase-3 bụ ihe na-adịghị mma na rheumatoid vasculitis.
Ọgwụgwọ Vasculitis Rheumatoid
Ọgwụgwọ nke rheumatoid vasculitis bụ nke a na-ekpebi akụkụ nke akụkụ ya.
Ọzọkwa, a ghaghị iji arthritis rheumatoid mee ihe n'ụzọ dị irè site na iji ọgwụ DMARD ma ọ bụ ọgwụ ndị dị ndụ, dị ka TNF blockers . Ịchịkwa mbufụt na nkwonkwo na n'ime ọbara dị mkpa.
Usoro mbụ nke ọgwụgwọ maka vascularitis rheumatoid gụnyere itinye corticosteroids (na-abụkarị prednisone ). Prednisone nwere ike ijikọta ya na usoro azatioprine. N'iji ihe mgbaàmà dị iche iche pụta na mkparịta ụka siri ike, itinyekwu mgbalị ike maka immunosuppression nwere ike ịgụnye cyclophosphamide yana usoro dị elu prednisone. Rituxan (rituximab) na -apụta dịka usoro ọgwụgwọ mbụ maka rheumatoid vasculitis. Dị ka akụkọ na Arthritis Care and Research (2012) si kwuo, nchọpụta nke data site na Autoimmunity na Rituximab ndekọ gosipụtara na remission e nwetara na 12 nke 17 ọrịa rurumatoid vasculitis agwọ na rituximab. Ndị ọrịa ahụ nwekwara ike ibelata dose nke prednisone.
Isi mmalite:
Vasculitis Rheumatoid. Johns Hopkins Vasculitis Center.
http://www.hopkinsvasculitis.org/types-vasculitis/rheumatoid-vasculitis/
Vasculitis Rheumatoid. Cleveland Clinic.
http://my.clevelandclinic.org/services/orthopaedics-rheumatology/diseases-conditions/hic-rheumatoid-vasculitis
Vasculitis Rheumatoid. Ụkpụrụ Vasculitis. Septemba 2012.
http://www.vasculitisfoundation.org/education/forms/rheumatoid-vasculitis/
Vasculitis Rheumatoid: Ịkwụsị Mena ma ọ bụ Ntube maka Ọgwụgwọ Ọhụrụ? Bọl na Bridges. Akụkọ Rheumatology nke Oge A. December 2010.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950222/
Ngwọta Rituximab maka vascularitis systemic metụtara ọrịa arthritis: Mmiri site na Nchekwa onwe na Rituximab. Puechal X et al. Nlekọta na Nyocha. March 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22076726