Ngwakọta Ọrịa Na-enye Ngwọta Ọgwụgwọ Dị Ukwuu maka Genotype 1 na 4 Ọrịa
Nhazi
Zepatier (elbasvir / grazoprevir) bụ ọgwụ a na-ejikọta ọnụ maka ọgwụgwọ ịba ọcha n'anya nke C (HCV) . Abụọ ọgwụ ọjọọ nke gụnyere Zepatier (elbasvir, grazoprevir) na-arụ ọrụ site na igbochi ma protein (NS5a) na enzyme (NS3 / 4a protease) dị mkpa maka ntinyeghachi nje ahụ.
Zepatier kwadoro na January 28, 2016 site n'aka US Food and Drug Administration (FDA) maka ndị okenye 18 afọ ma ọ bụ karịa na ọrịa HCV genotype 1 ma ọ bụ 4 , gụnyere ndị nwere cirrhosis.
A kwadoro maka ojiji ma na-agwọtaghị (ọgwụgwọ-naïve) ma ọ bụ na-emeso ndị ọrịa (ndị na-agwọ ọrịa), dabere na genotype HCV na ọnọdụ ọgwụgwọ.
Ike
A kọrọ Zepatier na ọ ga - enweta ọgwụgwọ a na - ahụkebe na nyocha nke mmadụ II. A na-akọwa ọgwụgwọ HCV ka ọ bụrụ na ị kwadoro ihe karịrị ọrịa iri abụọ na anọ mgbe ị gụsịrị ọgwụgwọ (nke a makwaara dịka mmeghachi omume ọgwụgwọ siri ike, ma ọ bụ SVR ).
Ọnụ ọgụgụ SVR n'ozuzu ya sitere na 94% ruo 97% na ndị ọrịa nwere ọrịa HCV genotype 1, ebe ndị ọrịa na genotype 4 ọrịa na-akọ na ha nwere ọnụego SVR nke 97% ruo 100%.
Ọgwụgwọ
Otu mbadamba nkume (50mg / 100mg) kwa ụbọchị ma ọ bụ na-enweghị nri. Mbadamba Zepatier bụ ụdị oval, acha agba aja aja na ihe nkiri, na "770" nke e jikọtara n'otu akụkụ.
Na-akọwa ndụmọdụ
Zepatier bụ onye na-eji ma ọ bụ na-enweghị ribavirin maka ọrịa genotype 1 ma ọ bụ 4. N'adịghị ka usoro ọgwụgwọ HCV gara aga, peginterferon (ọgwụ a jikọtara ya na mmetụta a na-enweghị ike imecha ) adịghị achọrọ.
Tupu ịmalite ịmalite ọgwụgwọ, a na-eme nnyocha mkpụrụ ndụ ihe nketa iji chọpụta ma ị nwere ụdị nje nke na-eguzogide ọgwụ na mpaghara elbasvir nke Zepatier (nke a maara dị ka polymorphism metụtara NS5a).
Ogologo oge ọgwụgwọ na-amalite site na izu 12-16, dabere na genotype HCV na ọnọdụ ọgwụgwọ.
| Genotype | Ọgwụgwọ ọnọdụ | Emere na ribavirin? | Oge |
| Genotype 1a | ọgwụgwọ-naịve na- enweghị elbasvir-na-eguzogide ọgwụ nje | Ee e | Izu iri na abụọ |
| ọgwụgwọ-naïve na elbasvir-eguzogide nje | ee | Izu iri na isii | |
| emeso ya na ribavirin + peginterferon na- enweghị ọgwụ elbasvir na-eguzogide | Ee e | Izu iri na abụọ | |
| emeso ya na ribavirin + peginterferon na ọrịa elbasvir na-eguzogide ọgwụ | ee | Izu iri na isii | |
| emeso ya na ribavirin + peginterferon + onye na-egbochi HCV protehibit | ee | Izu iri na abụọ | |
| Genotype 1b | ọgwụgwọ-naïve | Ee e | Izu iri na abụọ |
| emeso ya na ribavirin + peginterferon | Ee e | Izu iri na abụọ | |
| emeso ya na ribavirin + peginterferon + onye na-eme ihe nchebe HCV * | ee | Izu iri na abụọ | |
| Genotype 4 | ọgwụgwọ-naïve | Ee e | Izu iri na abụọ |
| emeso ya na ribavirin + peginterferon | ee | Izu iri na isii |
* - Olysio (simeprevir), Victrelis (boceprevir), Ntinye (telaprevir)
Mmetụta Na-agakarị
Ihe mmetụta kachasị emetụta metụtara Zepatier (nke na-eme ihe karịrị pasent 5) bụ:
- Ike ọgwụgwụ
- Isi ọwụwa
- Nausea
Mgbe a na - eji ribavirin, ihe a na - akpatakarị mmetụta ọgwụgwọ (nke na - eme na ihe karịrị mmadụ 5%) gụnyere:
- Isi ọwụwa
- Ike ọgwụgwụ
- Ahụhụ
- Nausea
- Ịdị ọcha
- Nri
- Obere ume
- Mkpụrụ obi
- Mgbu mgbu
- Enwekwu agụụ
- Nsogbu
- Mmetụta
- Rash
Mmekọrịta ọgwụ ọjọọ
A gaghị eji ọgwụ ndị na-esonụ eme ihe mgbe ị na-ewere Zepatier ka ha nwere ike ime ka mmekọrịta ọgwụ ọjọọ bara uru:
- Ugbo ogwu: Nafcillin
- Mkpụrụ akwụkwọ: Dilantin (phenytoin), Tegretol (carbamazepine)
- Ngwurugwu: Akwụkwọ mbadamba ụrọ Nizoral (ketoconazole)
- Ọgwụ ndị na-emegide ọrịa: Tracleer (bosentan)
- Ngwa ọka Herbal: St. John Wort
- Ọgwụ nje nje HIV: Aptivus (tipranavir), Genvoya (elvitegravir, cobicistat, emtricitabine, tenofovir alafenamide), Integrity (etravirine), Invirase (saquinavir), Kaletra (lopinavir, ritonavir), Prezista (darunavir), Reyataz (atazanvir), Stribild ( elvitegravir, cobicistat, emtricitabine, tenofovir disproxil), Sustiva (efavirenz),
- Ngwá ọgwụ ndị na-enye aka mgbochi iji gbochie ịjụ mkpụrụ akụkụ: cyclosporine
- Ngwọrọgwu Rifampin na-eji ọgwụgwọ ọrịa ụkwara nta: Mycobutin, Priftin, Rifater, Rifamate, Rimactane, Rifadin
Ntụle Ọgwụgwọ
Akwukwo ihe omuma bu na 1% nke ndi mmadu no na Zepatier meputara nnukwu onu enzymes imeju nke negosi imeju na imeju, n'ozuzu na ma obu mgbe izu nke izu asatọ. Ya mere, ọ dị mkpa ka a rụchaa ọbara nyocha nke ọrịa ime tupu ịmalite ọgwụgwọ na mgbe nile n'oge usoro ọgwụgwọ HCV.
Zepatier ekwesịghị ịbụ onye a ga-enye ndị ọrịa nwere nsogbu nchịkwa siri ike.
Ejila ribavirin mee ihe n'ime afọ ime ma ghara iji ọgwụ Zepatier ma ọ bụ ọgwụgwọ ịba ọcha n'anya nke C ọ bụla mee ihe. A ga - adụ ndị inyom na-arịa ọrịa ọgwụgwọ na ribavirin ka ha zere ime ime na iji usoro abụọ na-emeghị ọgwụgwọ nke ime mgbochi n'oge a na-agwọ ọrịa nakwa maka ọnwa isii mgbe ị gụsịrị ọgwụgwọ.
Isi:
Nchịkwa nri na ọgwụgwọ US (FDA). "FDA kwadoro Zepatier maka ịgwọ ọrịa ịba ọcha n'anya nke na-arịa ọrịa na-adịghị ala ala nke C na-arịa ọrịa 1 na nke 4." Silver Spring, Maryland; pịa ntọhapụ nyere January 28, 2016.
Merck. "Zepatier - Isi Ihe Na-akọwa Ozi." Kenilworth, New Jersey; wee banye na January 29, 2016.