Mkpụrụ pọmigranet ahụ , nke a na-ewere na ọ bụ ebe ochie, dị ugbu a na-ewu ewu. A na-achọta ihe ọṅụṅụ mbadamba pọmigranị n'ihe fọrọ nke nta ka ọ bụrụ ụlọ ahịa ọ bụla na North America.
Ma otu akụkọ e bipụtara na mbipụta nke September 1, 2006 nke magazin American Journal of Cardiology na- enye echiche na mkpụrụ pọmigranet nwere ike iji ọgwụ na-emekarị ihe.
Otu nwoke dị afọ 48 na-ewere ezetimibe (Zetia®) 10 mg n'ụbọchị na rosuvastatin (Crestor®) 5 mg ụbọchị ọ bụla maka ọnwa 17.
A na-eji ọgwụ abụọ eme ihe maka cholesterol dị elu.
Ọ malitere ịṅụ ihe ọṅụṅụ pọmigranet (200 ml ugboro abụọ kwa izu) na izu atọ mgbe e mesịrị, a nabatara mgbu mgbu ụkwụ na mpempe akwụkwọ na-emepụta ihe na-eme ka ọkpụkpụ creatine kinase (138,030 U / L, nkịtị <200 U / L). Abụọ bụ ihe mgbaàmà nke rhabdomyolysis, ọnọdụ dị njọ nke na-akpata nkwụsị nke ụbụrụ muscle ma nwee ike ịkpata ọdịda akụrụ.
Rosuvastatin bụ otu ìgwè ọgwụ a na-akpọ HMG-CoA reductase inhibitors, ma ọ bụ 'statins'. A maara ihe ọṅụṅụ mkpụrụ vaịn na-eme ka ihe omimi nke ihe ndị na-emepụta ihe na-emetụta ụbụrụ, ma ruo ugbu a, obere ihe ọmụma banyere ma ihe pọmigranet pụrụ ime ka ihe ize ndụ ahụ dịkwuo ukwuu.
Ihe ọṅụṅụ pọmigranet na mkpụrụ vaịn, bụ nke a maara iji gbochie usoro cyclochrome P450 3A4 usoro enzyme na eriri afọ. Site na igbochi enzymes ndị a, ndị na-aṅụ ihe ọṅụṅụ nwere ike ime ka ọtụtụ ọgwụ dịkwuo n'ọbara.
Mmekọrịta pọmigranet nwere ike ime ihe
- Antiarrhythmics - Amiodarone (Cordarone®), disopyramide (Norpace®), quinidine
- Ndị na - egbochi calcium - Felodipine (Plendil®), nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Ụkpụrụ - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®)
- Ndị na - emechi ihe nchebe - Saquinavir (Fortovase®)
Otú ọ dị, ihe ọṅụṅụ mkpụrụ pọmigranet nwekwara ike iji ọgwụ na-emekọrịta ihe na-adịghị na ndepụta a.
Achọghị ka ọgwụ ndị na-ezighi ezi na rosuvastatin kwatuo site na cytochrome P450 3A4.
Dabere na njirimara na-enweghị njedebe gbasara mmekọrịta ọgwụ ọjọọ, ọ dị mkpa ka gị na dọkịta gị kwurịta ma ọ bụrụ na ị na-aṅụ ọgwụ ma na-atụle ịṅụ mmanya pọmigranet.
Isi mmalite:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Mmetụta nke mkpụrụ pọmigranet na cytochrome mmadụ p450 3A (CYP3A) na carbamazepine pharmacokinetics na oke. Metabolism na Mgbochi. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Mmetụta ọjọọ nke mkpụrụ osisi mkpụrụ na CYP3A ọrụ. Metabolism na Mgbochi. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis jikọrọ ya na ihe ọṅụṅụ mkpụrụ pọmigranet. American Journal of Cardiology. 98.5 (2006): 705-6.
Disclaimer: Ihe ọmụma dị na saịtị a bu n'obi maka ebumnuche naanị ma ọ bụghị ihe mgbakwunye maka ndụmọdụ, nyocha ma ọ bụ ọgwụgwọ site na onye dọkịta nyere ikikere. Ekwesighi iji kpuchie ndokwa niile, ọgwụ ọjọọ, ọnọdụ ma ọ bụ mmetụta ọjọọ. Ị ga-achọ nlekọta ahụike ngwa ngwa maka nsogbu ahụike ọbụla ma jụọ dọkịta gị tupu i jiri ọgwụgwọ ọzọ ma ọ bụ gbanwee usoro gị.